Background Glucose oxidation is a major contributor to myocardial energy production and
its contribution is orchestrated by insulin. While insulin can increase glucose oxidation …

Mitochondrial oxidative phosphorylation is the major source of energy in cardiac muscle. In
the streptozotocin-induced diabetic (STZ-DM) mice, myocardial oxidative phosphorylation …

Aims: To determine the contribution of insulin signaling versus systemic metabolism to
metabolic and mitochondrial alterations in type 1 diabetic hearts and test the hypothesis that …

Cardiac glucose uptake and oxidation are reduced in diabetes despite hyperglycemia.
Mitochondrial dysfunction contributes to heart failure in diabetes. It is unclear whether these …

Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including
pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial …

Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …

Diabetes mellitus is one of the most common metabolic diseases in the world. The
complications associated with this disease are often responsible for a decreased quality of …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Background—Diabetes-associated cardiac dysfunction is associated with mitochondrial
dysfunction and oxidative stress, which may contribute to left ventricular dysfunction. The …

Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the
causal link between diabetes and diabetic complications. Four major molecular mechanisms …