Heart failure (HF) frequently coexists with conditions associated with glucose insufficiency,
such as insulin resistance and type 2 diabetes mellitus (T2DM), and patients with T2DM …

We have recently demonstrated that catalase content in mouse cardiac mitochondria is
selectively elevated in response to high dietary fat, a nutritional state associated with …

Interpreting mitochondrial function as affected by comparative physiologic conditions is
confounding because individual functional parameters are interdependent. Here, we studied …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …

All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to
meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the …

OBJECTIVE—Muscle mitochondrial dysfunction occurs in many insulin-resistant states, such
as type 2 diabetes, prompting a hypothesis that mitochondrial dysfunction may cause insulin …

Skeletal muscle is the major site of insulin-stimulated glucose utilization in the body. Central
to this process is oxidative metabolism, which is controlled by mitochondria. Therefore …

Large scale clinical trials have demonstrated that an intensive antihyperglycemic treatment
in diabetes mellitus (DM) in individuals reduces the incidence of micro-and macrovascular …

This study evaluated and compared the effect of insulin treatment on the status of brain,
heart and kidney mitochondria isolated from 12-week streptozotocin (STZ)-induced diabetic …

Many diabetic patients suffer from a cardiomyopathy that cannot be explained by poor
coronary perfusion. Reactive oxygen species (ROS) have been proposed to contribute to …