There has been growing interest in the potential anti-cancer activity of statins based on
evidence of their anti-proliferative, pro-apoptotic, and radiosensitizing properties, but no …

Cancer is incurable because progressive phenotypic and genotypic changes in cancer cells
lead to resistance and recurrence. This indicates the need for the development of new drugs …

As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Although it could be speculated that almost everything has been said concerning the use of
statins in cancer therapy, statins as anticancer drugs have both committed supporters and …

Despite significant, frequently very strong, antiproliferative and tumoricidal effects of statins
demonstrated in vitro, their antitumor effects in animal models are modest, and their efficacy …

About seven million people die of cancer every year. This is largely due to development of
drug resistance, particularly multidrug resistance, in the tumor cells. Multidrug resistance …

Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …

Abstract Statins [3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase,
abbreviated HMGCR) inhibitors], are well-known cholesterol-depleting agents. Since the …

Simple Summary Statins are crucial for managing lipid disorders by inhibiting HMG-CoA
reductase, reducing cholesterol levels, and lowering cardiovascular disease risk. Beyond …

After initial concerns regarding the association of statins with increased incidences of cancer
and elevated cancer-related mortality, there are now plenty of data on the antitumor …