Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness

J Joo, ACY Mak, S Xiao, PM Sleiman, D Hu… - Scientific reports, 2022 - nature.com
Variability in response to short-acting β2-agonists (eg, albuterol) among patients with
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …

Whole-genome sequencing of pharmacogenetic drug response in racially diverse children with asthma

ACY Mak, MJ White, WL Eckalbar… - American journal of …, 2018 - atsjournals.org
Rationale: Albuterol, a bronchodilator medication, is the first-line therapy for asthma
worldwide. There are significant racial/ethnic differences in albuterol drug response …

A genome-wide association study of bronchodilator response in Latinos implicates rare variants

KA Drake, DG Torgerson, CR Gignoux… - Journal of allergy and …, 2014 - Elsevier
Background The primary rescue medication to treat acute asthma exacerbation is the short-
acting β 2-adrenergic receptor agonist; however, there is variation in how well a patient …

Pharmacogenetic polygenic risk score for bronchodilator response in children and adolescents with asthma: proof-of-concept

JE Sordillo, SM Lutz, MJ McGeachie… - Journal of Personalized …, 2021 - mdpi.com
Genome-wide association studies (GWAS) of response to asthma medications have
primarily focused on Caucasian populations, with findings that may not be generalizable to …

A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

ML Spear, D Hu, M Pino-Yanes, S Huntsman… - The …, 2019 - nature.com
Short-acting β2-adrenergic receptor agonists (SABAs) are the most commonly prescribed
asthma medications worldwide. Response to SABAs is measured as bronchodilator drug …

Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age‐related trends by genotype

JE Sordillo, M McGeachie, SM Lutz… - Pediatric …, 2019 - Wiley Online Library
Abstract Background and Objectives Genome Wide Association Studies (GWAS) have
identified genetic polymorphisms associated with bronchodilator response (BDR), but it is …

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function

PC Goddard, KL Keys, ACY Mak, EY Lee… - Genetic …, 2021 - Wiley Online Library
Bronchodilator (BD) drugs are commonly prescribed for treatment and management of
obstructive lung function present with diseases such as asthma. Administration of BD …

Genome-Wide Association Study of Short-Acting β2-Agonists. A Novel Genome-Wide Significant Locus on Chromosome 2 near ASB3

E Israel, J Lasky-Su, A Markezich… - American journal of …, 2015 - atsjournals.org
Rationale: β2-Agonists are the most common form of treatment of asthma, but there is
significant variability in response to these medications. A significant proportion of this …

Genomic predictors of asthma phenotypes and treatment response

N Hernandez-Pacheco, M Pino-Yanes… - Frontiers in …, 2019 - frontiersin.org
Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …

Genetic predictors of response to therapy in childhood asthma

SW Turner - Molecular Diagnosis & Therapy, 2009 - Springer
Asthma is a common chronic condition in children, where the response to treatment can be
heterogeneous within a population. Genetic variations may partly explain the inconsistent …