Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness
Variability in response to short-acting β2-agonists (eg, albuterol) among patients with
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …
asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to …
Whole-genome sequencing of pharmacogenetic drug response in racially diverse children with asthma
ACY Mak, MJ White, WL Eckalbar… - American journal of …, 2018 - atsjournals.org
Rationale: Albuterol, a bronchodilator medication, is the first-line therapy for asthma
worldwide. There are significant racial/ethnic differences in albuterol drug response …
worldwide. There are significant racial/ethnic differences in albuterol drug response …
A genome-wide association study of bronchodilator response in Latinos implicates rare variants
KA Drake, DG Torgerson, CR Gignoux… - Journal of allergy and …, 2014 - Elsevier
Background The primary rescue medication to treat acute asthma exacerbation is the short-
acting β 2-adrenergic receptor agonist; however, there is variation in how well a patient …
acting β 2-adrenergic receptor agonist; however, there is variation in how well a patient …
Pharmacogenetic polygenic risk score for bronchodilator response in children and adolescents with asthma: proof-of-concept
Genome-wide association studies (GWAS) of response to asthma medications have
primarily focused on Caucasian populations, with findings that may not be generalizable to …
primarily focused on Caucasian populations, with findings that may not be generalizable to …
A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma
ML Spear, D Hu, M Pino-Yanes, S Huntsman… - The …, 2019 - nature.com
Short-acting β2-adrenergic receptor agonists (SABAs) are the most commonly prescribed
asthma medications worldwide. Response to SABAs is measured as bronchodilator drug …
asthma medications worldwide. Response to SABAs is measured as bronchodilator drug …
Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age‐related trends by genotype
Abstract Background and Objectives Genome Wide Association Studies (GWAS) have
identified genetic polymorphisms associated with bronchodilator response (BDR), but it is …
identified genetic polymorphisms associated with bronchodilator response (BDR), but it is …
Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function
Bronchodilator (BD) drugs are commonly prescribed for treatment and management of
obstructive lung function present with diseases such as asthma. Administration of BD …
obstructive lung function present with diseases such as asthma. Administration of BD …
Genome-Wide Association Study of Short-Acting β2-Agonists. A Novel Genome-Wide Significant Locus on Chromosome 2 near ASB3
E Israel, J Lasky-Su, A Markezich… - American journal of …, 2015 - atsjournals.org
Rationale: β2-Agonists are the most common form of treatment of asthma, but there is
significant variability in response to these medications. A significant proportion of this …
significant variability in response to these medications. A significant proportion of this …
Genomic predictors of asthma phenotypes and treatment response
N Hernandez-Pacheco, M Pino-Yanes… - Frontiers in …, 2019 - frontiersin.org
Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …
Genetic predictors of response to therapy in childhood asthma
SW Turner - Molecular Diagnosis & Therapy, 2009 - Springer
Asthma is a common chronic condition in children, where the response to treatment can be
heterogeneous within a population. Genetic variations may partly explain the inconsistent …
heterogeneous within a population. Genetic variations may partly explain the inconsistent …