Sex hormones regulate lipid metabolism in adult Sertoli cells: A genome-wide study of estrogen and androgen receptor binding sites

S Raut, AV Kumar, S Deshpande, K Khambata… - The Journal of Steroid …, 2021 - Elsevier
Optimal functioning of Sertoli cells is crucial for spermatogenesis which is under tight
regulation of sex hormones, estrogen and androgen. Adult rat Sertoli cells expresses …

Genome-wide identification of estrogen receptor binding sites reveals novel estrogen-responsive pathways in adult male germ cells

S Raut, AV Kumar, K Khambata… - Biochemical …, 2020 - portlandpress.com
Spermatogenesis occurs in the seminiferous epithelium that shows the presence of estrogen
receptors alpha (ERα) and beta (ERβ), both of which regulate gene transcription by binding …

Research resource: the dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis

C Zimmermann, I Stévant, C Borel… - Molecular …, 2015 - academic.oup.com
Sertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately
with developing germ cells. They not only provide physical and nutritional support but also …

Characterization of cholesterol metabolism in Sertoli cells and spermatogenesis

JF Shi, YK Li, K Ren, YJ Xie… - Molecular medicine …, 2018 - spandidos-publications.com
The Sertoli cell, which is the supporting cell of spermatogenesis, has an important role in the
endocrine and paracrine control of spermatogenesis. Functionally, it provides the cells of the …

New insights on hormones and factors that modulate Sertoli cell metabolism

L Rato, MJ Meneses, BM Silva, M Sousa, MG Alves… - 2016 - digitum.um.es
Sertoli cells (SCs) play a key role in spermatogenesis by providing the physical support for
developing germ cells and ensuring them the appropriate nutrients, energy sources …

Molecular mechanisms and signaling pathways involved in the nutritional support of spermatogenesis by Sertoli cells

L Crisóstomo, MG Alves, A Gorga, M Sousa… - Sertoli Cells: Methods …, 2018 - Springer
Sertoli cells play a central role in spermatogenesis. They maintain the blood-testis barrier,
an essential feature of seminiferous tubules which creates the proper environment for the …

Do estrogens regulate lipid status in testicular steroidogenic Leydig cell?

A Milon, M Kaczmarczyk, P Pawlicki, B Bilinska… - Acta histochemica, 2019 - Elsevier
In this study mouse Leydig cell (MA-10) were treated with G-protein coupled membrane
estrogen receptor antagonist (G-15; 10 nM). Cells were analyzed by Western blotting for …

Hormonal control of Sertoli cell metabolism regulates spermatogenesis

MG Alves, L Rato, RA Carvalho, PI Moreira… - Cellular and molecular …, 2013 - Springer
Hormonal regulation is essential to spermatogenesis. Sertoli cells (SCs) have functions that
reach far beyond the physical support of germ cells, as they are responsible for creating the …

[HTML][HTML] Single-cell RNA sequencing defines the regulation of spermatogenesis by Sertoli-cell androgen signaling

C Cao, Q Ma, S Mo, G Shu, Q Liu, J Ye… - Frontiers in Cell and …, 2021 - frontiersin.org
Androgen receptor (AR) signaling is essential for maintaining spermatogenesis and male
fertility. However, the molecular mechanisms by which AR acts between male germ cells …

Lipid metabolism is closely associated with normal testicular growth based on global transcriptome profiles in normal and underdeveloped testis of obese zucker (fa/fa …

J Datar, A Regassa, WK Kim, CG Taylor, P Zahradka… - Lipids, 2017 - Springer
Zucker (fa/fa) obese rats often have non-identical and differently sized paired testes, leaving
one testis underdeveloped. Our earlier study found that the underdeveloped testes,> 30 …