Upfront cranial radiotherapy followed by erlotinib positively affects clinical outcomes of epidermal growth factor receptor-mutant non-small cell lung cancer with brain …
K Saruwatari, T Ikeda, S Saeki, N Shingu… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: The optimal treatment strategy for epidermal growth factor receptor (EGFR)-
mutant non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) has not yet …
mutant non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) has not yet …
[HTML][HTML] Tyrosine Kinase Inhibitors Could Be Effective Against Non-small Cell Lung Cancer Brain Metastases Harboring Uncommon EGFR Mutations
C Ma, J Zhang, D Tang, X Ye, J Li, N Mu, Z Li… - Frontiers in …, 2020 - frontiersin.org
Background: The significance of uncommon epidermal growth factor receptor (EGFR)
mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) …
mutations in patients with non-small cell lung cancer (NSCLC) and brain metastasis (BM) …
Impact of whole brain radiation therapy on CSF penetration ability of Icotinib in EGFR-mutated non-small cell lung cancer patients with brain metastases: results of …
L Zhou, J He, W Xiong, Y Liu, J Xiang, Q Yu, M Liang… - Lung Cancer, 2016 - Elsevier
Objectives Whole-brain radiation therapy (WBRT) and epidermal growth factor receptor
tyrosine kinase inhibitors (EGFR-TKIs) are both treatment options for EGFR-mutated non …
tyrosine kinase inhibitors (EGFR-TKIs) are both treatment options for EGFR-mutated non …
Role of chemotherapy on brain metastasis
SH Lee - Current and Future Management of Brain Metastasis, 2012 - karger.com
Cytotoxic chemotherapy has been considered ineffective for brain metastasis, traditionally
because of poor penetration across the blood-brain barrier. However, cytotoxic …
because of poor penetration across the blood-brain barrier. However, cytotoxic …
Enhanced efficacy of AZD3759 and radiation on brain metastasis from EGFR mutant non‐small cell lung cancer
X Li, Y Wang, J Wang, T Zhang, L Zheng… - … Journal of Cancer, 2018 - Wiley Online Library
The prognosis of patients with brain metastasis (BM) is poor. In our study, we demonstrated
that AZD3759, an EGFR tyrosine kinase inhibitors (TKIs) with excellent blood–brain barrier …
that AZD3759, an EGFR tyrosine kinase inhibitors (TKIs) with excellent blood–brain barrier …
Overall survival benefit of osimertinib and clinical value of upfront cranial local therapy in untreated EGFR‐mutant nonsmall cell lung cancer with brain metastasis
Y Zhao, S Li, X Yang, L Chu, S Wang… - … journal of cancer, 2022 - Wiley Online Library
Osimertinib, as a third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitor (TKI), showed more potent efficacy against brain metastasis (BM) in untreated …
inhibitor (TKI), showed more potent efficacy against brain metastasis (BM) in untreated …
Determination of intracellular anlotinib, osimertinib, afatinib and gefitinib accumulations in human brain microvascular endothelial cells by liquid chromatography …
Z Ma, S Lu, H Zhou, S Zhang… - … in Mass Spectrometry, 2021 - Wiley Online Library
Rationale Brain metastases are a common complication in patients with non‐small‐cell lung
cancer (NSCLC). Anlotinib hydrochloride is a novel multi‐target tyrosine kinase inhibitor …
cancer (NSCLC). Anlotinib hydrochloride is a novel multi‐target tyrosine kinase inhibitor …
[HTML][HTML] Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial
GL Ceresoli, F Cappuzzo, V Gregorc, S Bartolini… - Annals of oncology, 2004 - Elsevier
Background: Brain metastases are a common occurrence in patients with non-small-cell
lung cancer (NSCLC). Whole-brain radiotherapy (WBRT) is the standard therapy; more …
lung cancer (NSCLC). Whole-brain radiotherapy (WBRT) is the standard therapy; more …
[HTML][HTML] A comparative analysis of EGFR mutation status in association with the efficacy of TKI in combination with WBRT/SRS/surgery plus chemotherapy in brain …
L Cai, J Zhu, X Zhang, S Lin, X Su, P Lin, K Chen… - Journal of neuro …, 2014 - Springer
We proposed to identify the efficacy of an epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery …
kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery …