Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …

HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …

The latent reservoir for HIV-1 in resting CD4+ T cells is a major barrier to cure. Several lines
of evidence suggest that the latent reservoir is maintained through cellular proliferation …

Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …

The discovery of a stable latent reservoir for HIV‐1 in resting memory CD4+ T cells provides
a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist …

Palmer S, Josefsson L, Coffin JM (Karolinska Institutet, Solna; Swedish Institute for Infectious
Disease Control, Solna, Sweden; and Tufts University, Boston, MA, USA). HIV reservoirs and …

The latent reservoir of HIV-1 in resting CD4+ T cells is a major barrier to cure. It is unclear
whether the latent reservoir resides principally in particular subsets of CD4+ T cells, a …

Despite the remarkable success of highly active antiretroviral therapy (HAART) for the
treatment of HIV-1 infection, it now appears that the infection is intrinsically incurable with …