Background Reduction of precuneus choline acetyltransferase activity co-occurs with
greater beta-amyloid (Aβ) in Alzheimer's disease (AD). Whether this cholinergic deficit is …

Hippocampal precursor of nerve growth factor (proNGF)/NGF signaling occurs in
conjunction with β-amyloid (Aβ) accumulations in Alzheimer disease (AD). To assess the …

Objective Selective neuronal vulnerability in neurodegenerative diseases is poorly
understood. In Alzheimer's disease, the basal forebrain cholinergic neurons are selectively …

Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe
memory circuit, are selectively vulnerable during the progression of Alzheimer's disease …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of
Alzheimer's disease (AD). Loss of synapses between basal forebrain and hippocampal and …

Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity
receptors has been suggested to underlie the selective degeneration of the nucleus basalis …

The degeneration of cholinergic basal forebrain (cBF) neurons in Alzheimer's disease (AD)
leads to the cognitive impairment associated with this condition. cBF neurons express the …

Objective: This study examined the relationship between postmortem precuneus cholinergic
enzyme activity, Pittsburgh compound B (PiB) binding, and soluble amyloid-β concentration …

In Alzheimer's disease and Down syndrome, cholinergic neurons of the basal forebrain
progressively degenerate. This neurotransmitter system is the main source of acetylcholine …