A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Mechanisms that regulate host defense after noninfectious tissue injury are incompletely
understood. Our laboratory is interested in the role of the extracellular matrix …

Mechanisms that regulate inflammation and repair after acute lung injury are incompletely
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

Hyaluronan is an unbiquitous glycosaminoglycan present in most tissues. Under
homeostatic conditions hyaluronan exists as a high molecular mass polymer that has …

Wound healing involves a series of carefully modulated steps, from initial injury and blood
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …

Hyaluronan (HA), a major extracellular matrix macromolecule, has a repeated disaccharide
structure that is completely conserved throughout a large span of evolution, indicating a …

Inflammation under sterile conditions is not well understood despite its importance in trauma
and autoimmune disease. To investigate this process we established mouse models of …

The polysaccharide hyaluronan is an essential component of the vertebrate extracellular
matrix and also produced by viruses, bacteria and fungi. Although the hyaluronan polymer is …