[HTML][HTML] The dual role of poly (ADP-ribose) polymerase-1 in modulating parthanatos and autophagy under oxidative stress in rat cochlear marginal cells of the stria …
Oxidative stress is reported to regulate several apoptotic and necrotic cell death pathways in
auditory tissues. Poly (ADP-ribose) polymerase-1 (PARP-1) can be activated under …
auditory tissues. Poly (ADP-ribose) polymerase-1 (PARP-1) can be activated under …
[HTML][HTML] Decreased poly (ADP-ribose) polymerase 1 expression attenuates glucose oxidase-induced damage in rat cochlear marginal strial cells
Y Zhang, Y Yang, Z Xie, W Zuo, H Jiang, X Zhao… - Molecular …, 2016 - Springer
Oxidative damage to the inner ear is responsible for several types of sensorineural
deafness. Cochlear stria marginal cells (MCs) are thought to be vulnerable to such oxidative …
deafness. Cochlear stria marginal cells (MCs) are thought to be vulnerable to such oxidative …
The autophagy pathway maintained signaling crosstalk with the Keap1–Nrf2 system through p62 in auditory cells under oxidative stress
K Hayashi, K Dan, F Goto, N Tshuchihashi, Y Nomura… - Cellular signalling, 2015 - Elsevier
The main purposes of our study were to consider the effect of autophagy on auditory cells
under oxidative stress, and the function of possible crosstalk among p62, Keap1 and Nrf2 in …
under oxidative stress, and the function of possible crosstalk among p62, Keap1 and Nrf2 in …
[HTML][HTML] D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice
Z Peng, C Zhao, Z Yang, S Gong, Z Du - BMC Molecular and Cell Biology, 2023 - Springer
Background Age-related hearing loss, known as presbycusis, is the result of auditory system
degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and …
degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and …
NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats
Z Du, Q Yang, L Liu, S Li, J Zhao, J Hu, C Liu, D Qian… - Neuroscience, 2015 - Elsevier
Aging has been associated with oxidative stress and the accumulation of mitochondrial DNA
(mtDNA) mutation. The previous study has established a mimetic rat model of aging using d …
(mtDNA) mutation. The previous study has established a mimetic rat model of aging using d …
Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea
J Menardo, Y Tang, S Ladrech, M Lenoir… - Antioxidants & redox …, 2012 - liebertpub.com
Aims: In our aging society, age-related hearing loss (ARHL) or presbycusis is increasingly
important. Here, we study the mechanism of ARHL using the senescence-accelerated …
important. Here, we study the mechanism of ARHL using the senescence-accelerated …
NADPH oxidase inhibitor apocynin decreases mitochondrial dysfunction and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging model in rats
ZD Du, S Yu, Y Qi, TF Qu, L He, W Wei, K Liu… - Neurochemistry …, 2019 - Elsevier
Presbycusis has become a common sensory deficit in humans. Oxidative damage to
mitochondrial DNA and mitochondrial dysfunction is strongly associated with the aging of …
mitochondrial DNA and mitochondrial dysfunction is strongly associated with the aging of …
Autophagy protects auditory hair cells against neomycin-induced damage
Z He, L Guo, Y Shu, Q Fang, H Zhou, Y Liu, D Liu… - Autophagy, 2017 - Taylor & Francis
Aminoglycosides are toxic to sensory hair cells (HCs). Macroautophagy/autophagy is an
essential and highly conserved self-digestion pathway that plays important roles in the …
essential and highly conserved self-digestion pathway that plays important roles in the …
[HTML][HTML] Effects of peroxisome proliferator activated receptors (PPAR)-γ and-α agonists on cochlear protection from oxidative stress
M Sekulic-Jablanovic, V Petkovic, MB Wright… - PloS one, 2017 - journals.plos.org
Various insults cause ototoxicity in mammals by increasing oxidative stress leading to
apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; eg, pioglitazone) and …
apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; eg, pioglitazone) and …
[HTML][HTML] The antioxidative role of autophagy in hearing loss
B Ye, C Fan, Y Shen, Q Wang, H Hu… - Frontiers in …, 2019 - frontiersin.org
Autophagy, a highly conserved cellular mechanism, plays an essential role in the
development and pathology of many central and peripheral nervous system diseases. The …
development and pathology of many central and peripheral nervous system diseases. The …