Function of GSK‑3 signaling in spinal cord injury
X Dong, H Hong, Z Cui - Experimental and Therapeutic …, 2023 - spandidos-publications.com
Spinal cord injury (SCI) is a major social problem with a heavy burden on patient physiology
and psychology. Glial scar formation and irreversible neuron loss are the two key points …
and psychology. Glial scar formation and irreversible neuron loss are the two key points …
Role of GSK3 in peripheral nerve regeneration
H Diekmann, D Fischer - Neural regeneration research, 2015 - journals.lww.com
In recent years, GSK3 has emerged as a key regulatory kinase in the nervous system, which
is involved in diverse processes ranging from neural development to mood stabilization to …
is involved in diverse processes ranging from neural development to mood stabilization to …
GSK‐3 Inhibitor promotes neuronal cell regeneration and functional recovery in a rat model of spinal cord injury
F Lei, W He, X Tian, Q Zhou, L Zheng… - BioMed research …, 2019 - Wiley Online Library
The reparative process following spinal cord injury (SCI) is extremely complicated. Cells in
the microenvironment express multiple inhibitory factors that affect axonal regeneration over …
the microenvironment express multiple inhibitory factors that affect axonal regeneration over …
Promotion of functional nerve regeneration by inhibition of microtubule detyrosination
P Gobrecht, A Andreadaki, H Diekmann… - Journal of …, 2016 - Soc Neuroscience
Functional recovery of injured peripheral neurons often remains incomplete, but the clinical
outcome can be improved by increasing the axonal growth rate. Adult transgenic …
outcome can be improved by increasing the axonal growth rate. Adult transgenic …
Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase‐3 inhibition
F Renault‐Mihara, H Katoh, T Ikegami… - EMBO molecular …, 2011 - embopress.org
The migratory response of astrocytes is essential for restricting inflammation and preserving
tissue function after spinal cord injury (SCI), but the mechanisms involved are poorly …
tissue function after spinal cord injury (SCI), but the mechanisms involved are poorly …
Sustained GSK3 activity markedly facilitates nerve regeneration
P Gobrecht, M Leibinger, A Andreadaki… - Nature …, 2014 - nature.com
Promotion of axonal growth of injured DRG neurons improves the functional recovery
associated with peripheral nerve regeneration. Both isoforms of glycogen synthase kinase 3 …
associated with peripheral nerve regeneration. Both isoforms of glycogen synthase kinase 3 …
Glycogen synthase kinase 3 beta (GSK3β) at the tip of neuronal development and regeneration
O Seira, JA Del Río - Molecular neurobiology, 2014 - Springer
Gaining a basic understanding of the inhibitory molecules and the intracellular signaling
involved in axon development and repulsion after neural lesions is of clear biomedical …
involved in axon development and repulsion after neural lesions is of clear biomedical …
PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias
SK Bareiss, E Dugan, KL Brewer - Molecular pain, 2015 - journals.sagepub.com
Background Neuropathic pain and sensory abnormalities are a debilitating secondary
consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining …
consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining …
Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS
J Dill, H Wang, F Zhou, S Li - Journal of Neuroscience, 2008 - Soc Neuroscience
Axonal regeneration is minimal after CNS injuries in adult mammals and medical treatments
to recover neurological deficits caused by axon disconnection are extremely limited. The …
to recover neurological deficits caused by axon disconnection are extremely limited. The …
Inhibition of gecko GSK‐3β promotes elongation of neurites and oligodendrocyte processes but decreases the proliferation of blastemal cells
Y Wang, Q Gu, Y Dong, W Zhou, H Song… - Journal of cellular …, 2012 - Wiley Online Library
GSK‐3β signaling is involved in regulation of both neuronal and glial cell functions, and
interference of the signaling affects central nervous system (CNS) development and …
interference of the signaling affects central nervous system (CNS) development and …