Effect of interleukin-6,-17,-21,-22, and-23 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis
I Woś, J Tabarkiewicz - Immunologic Research, 2021 - Springer
Rheumatic diseases are complex autoimmune diseases which include among others
rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA) …
rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA) …
STAT3 and NF-κB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
ML Cho, JW Kang, YM Moon, HJ Nam… - The Journal of …, 2006 - journals.aai.org
IL-23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-
23 has proinflammatory activity, inducing IL-17 secretion from activated CD4+ T cells and …
23 has proinflammatory activity, inducing IL-17 secretion from activated CD4+ T cells and …
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis
Inflammatory mediators have been recognized as being important in the pathogenesis of
rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and …
rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and …
The role of interleukin 6 in the pathophysiology of rheumatoid arthritis
S Srirangan, EH Choy - Therapeutic advances in …, 2010 - journals.sagepub.com
Interleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of
rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients …
rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients …
Significance of interleukin (IL)-4 and IL-13 in inflammatory arthritis
M Iwaszko, S Biały, K Bogunia-Kubik - Cells, 2021 - mdpi.com
Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-
5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important …
5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important …
[HTML][HTML] The physiological and pathophysiological role of IL-6/STAT3-mediated signal transduction and STAT3 binding partners in therapeutic applications
T Matsuda - Biological and Pharmaceutical Bulletin, 2023 - jstage.jst.go.jp
Abstract The interleukin 6 (IL-6) family of cytokines is defined by the usage of gp130, a
common β-receptor signaling subunit, which promotes a variety of signals. They induce …
common β-receptor signaling subunit, which promotes a variety of signals. They induce …
The roles of interleukin‐6 in the pathogenesis of rheumatoid arthritis
M Hashizume, M Mihara - Arthritis, 2011 - Wiley Online Library
Several clinical studies have demonstrated that the humanized anti‐interleukin‐6 (IL‐6)
receptor antibody tocilizumab (TCZ) improves clinical symptoms and prevents progression …
receptor antibody tocilizumab (TCZ) improves clinical symptoms and prevents progression …
Synoviocytes and skin fibroblasts show opposite effects on IL-23 production and IL-23 receptor expression during cell interactions with immune cells
M Noack, P Miossec - Arthritis Research & Therapy, 2022 - Springer
Abstract Background The IL-23/IL-17 axis is involved in inflammatory diseases including
arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different …
arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different …
Interleukin-7 in rheumatoid arthritis
SM Churchman, F Ponchel - Rheumatology, 2008 - academic.oup.com
Recent data from several groups demonstrate high levels of IL-7 in the joints of RA patients,
but much lower levels in OA. In contrast, circulating levels of IL-7 in RA remain a point of …
but much lower levels in OA. In contrast, circulating levels of IL-7 in RA remain a point of …
Functional role of IL-22 in psoriatic arthritis
A Mitra, SK Raychaudhuri, SP Raychaudhuri - Arthritis research & therapy, 2012 - Springer
Abstract Introduction Interleukin-22 (IL-22) is a cytokine of IL-10 family with significant
proliferative effect on different cell lines. Immunopathological role of IL-22 has been studied …
proliferative effect on different cell lines. Immunopathological role of IL-22 has been studied …