Entner-Doudoroff pathway in Synechocystis PCC 6803: Proposed regulatory roles and enzyme multifunctionalities

A Bachhar, J Jablonsky - Frontiers in Microbiology, 2022 - frontiersin.org
The Entner-Doudoroff pathway (ED-P) was established in 2016 as the fourth glycolytic
pathway in Synechocystis sp. PCC 6803. ED-P consists of two reactions, the first catalyzed …

Interplay between photosynthetic electron flux and organic carbon sinks in sucrose-excreting Synechocystis sp. PCC 6803 revealed by omics approaches

D Muth-Pawlak, L Kakko, P Kallio, EM Aro - Microbial Cell Factories, 2024 - Springer
Background Advancing the engineering of photosynthesis-based prokaryotic cell factories is
important for sustainable chemical production and requires a deep understanding of the …

GC/MS-based 13C metabolic flux analysis resolves the parallel and cyclic photomixotrophic metabolism of Synechocystis sp. PCC 6803 and selected deletion …

D Schulze, M Kohlstedt, J Becker, E Cahoreau… - Microbial Cell …, 2022 - Springer
Background Cyanobacteria receive huge interest as green catalysts. While exploiting
energy from sunlight, they co-utilize sugar and CO2. This photomixotrophic mode enables …

Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis species PCC6803

L Gao, C Shen, L Liao, X Huang, K Liu, W Wang… - Molecular & Cellular …, 2014 - ASBMB
The unicellular photosynthetic model-organism cyanobacterium Synechocystis sp.
PCC6803 can grow photoautotrophically using CO 2 or heterotrophically using glucose as …

Unconventional biochemical regulation of the oxidative pentose phosphate pathway in the model cyanobacterium Synechocystis sp. PCC 6803

S Ito, T Osanai - Biochemical Journal, 2020 - portlandpress.com
Metabolite production from carbon dioxide using sugar catabolism in cyanobacteria has
been in the spotlight recently. Synechocystis sp. PCC 6803 (Synechocystis 6803) is the most …

The Entner–Doudoroff pathway is an overlooked glycolytic route in cyanobacteria and plants

X Chen, K Schreiber, J Appel… - Proceedings of the …, 2016 - National Acad Sciences
Glucose degradation pathways are central for energy and carbon metabolism throughout all
domains of life. They provide ATP, NAD (P) H, and biosynthetic precursors for amino acids …

Cyanobacterial carbon metabolism: Fluxome plasticity and oxygen dependence

N Wan, DM DeLorenzo, L He, L You… - Biotechnology and …, 2017 - Wiley Online Library
Synechocystis sp. strain PCC 6803 has been widely used as a photo‐biorefinery chassis.
Based on its genome annotation, this species contains a complete TCA cycle, an Embden …

Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis sp. PCC6803

W Du, SA Angermayr, JA Jongbloets… - ACS synthetic …, 2017 - ACS Publications
Cyanobacteria are mostly engineered to be sustainable cell-factories by genetic
manipulations alone. Here, by modulating the concentration of allosteric effectors, we focus …

Production of succinate by engineered strains of Synechocystis PCC 6803 overexpressing phosphoenolpyruvate carboxylase and a glyoxylate shunt

C Durall, K Kukil, JA Hawkes, A Albergati… - Microbial cell …, 2021 - Springer
Background Cyanobacteria are promising hosts for the production of various industrially
important compounds such as succinate. This study focuses on introduction of the glyoxylate …

The Entner-Doudoroff Pathway Contributes to Glycogen Breakdown During High to Low CO2 Shifts in the Cyanobacterium Synechocystis sp. PCC 6803

S Lucius, A Makowka, K Michl, K Gutekunst… - Frontiers in Plant …, 2021 - frontiersin.org
Cyanobacteria perform plant-like oxygenic photosynthesis to convert inorganic carbon into
organic compounds and can also use internal carbohydrate reserves under specific …