Skeletal muscle in vertebrates is formed by two major routes, as illustrated by the mouse
embryo. Somites give rise to myogenic progenitors that form all of the muscles of the trunk …

During embryogenesis, skeletal muscle forms in the vertebrate limb from progenitor cells
originating in the somites. These cells delaminate from the hypaxial edge of the dorsal part …

To understand how the skeletal muscle lineage is induced during vertebrate
embryogenesis, we have sought to identify the regulatory molecules that mediate induction …

The morphological events forming the body's musculature are sensitive to genetic and
environmental perturbations with high incidence of congenital myopathies, muscular …

Research in the past year has added to our understanding of the signalling systems that
specify myogenic identity in the embryo and of the regulation and roles of MyoD family …

In vertebrates, the skeletal muscles of the body and their associated stem cells originate
from muscle progenitor cells, during development. The specification of the muscles of the …

▪ Abstract Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are
providing new insights into the regulatory functions of the myogenic regulatory factors …

Abstract We analyzed Pax-3 (splotch) Myf-5 (targeted with nlacZ), and splotch/Myf-5
homozygous mutant mice to investigate the roles that these genes play in programming …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …