The draining lymph node in rheumatoid arthritis: current concepts and research perspectives

F Benaglio, B Vitolo, M Scarabelli… - BioMed research …, 2015 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown
aetiology, leading to progressive damage of bone and cartilage with functional impairment …

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

EM Bouta, RD Bell, H Rahimi, L Xing… - Nature Reviews …, 2018 - nature.com
Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved
with the use of biologic and conventional DMARDs, approximately 40% of patients do not …

Tertiary lymphoid organs in rheumatoid arthritis

F Rivellese, E Pontarini, C Pitzalis - Inducible lymphoid organs, 2020 - Springer
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. RA mainly affects the
joints, with inflammation of the synovial membrane, characterized by hyperplasia, neo …

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

A Manzo, M Bombardieri, F Humby… - Immunological …, 2010 - Wiley Online Library
Rheumatoid arthritis is a chronic systemic inflammatory disease primarily affecting the
synovium of diarthrodial joints. Despite the currently unknown etiology, overwhelming …

Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential

H Rahimi, R Bell, EM Bouta, RW Wood, L Xing… - Arthritis Research & …, 2016 - Springer
Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node
volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore …

[HTML][HTML] Role of synovial lymphatic function in osteoarthritis

M Cao, MTY Ong, PSH Yung, RS Tuan… - Osteoarthritis and Cartilage, 2022 - Elsevier
Background Osteoarthritis (OA) affects the entire joint, initially with a low degree of
inflammation. Synovitis is correlated with the severity of OA clinical symptoms and cartilage …

Lymphoid microstructures in rheumatoid synovitis

CM Weyand, A Braun, S Takemura… - Current directions in …, 2001 - books.google.com
The lesion of rheumatoid arthritis (RA) is a tissue infiltrate of inflammatory cells accumulating
in the synovial membrane. Tissue-infiltrating cells are lymphocytes and macrophages; …

[HTML][HTML] Lymphatic vessels: Roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis

S Zhou, G Zhao, R Chen, Y Li, J Huang, L Kuang… - Theranostics, 2024 - ncbi.nlm.nih.gov
Lymphatic vessel networks are a main part of the vertebrate cardiovascular system, which
participate in various physiological and pathological processes via regulation of fluid …

Power Doppler ultrasonographic assessment of the joint-draining lymph node complex in rheumatoid arthritis: a prospective, proof-of-concept study on treatment with …

A Manzo, F Benaglio, B Vitolo, C Bortolotto… - Arthritis Research & …, 2016 - Springer
Background Emerging research on the mechanisms of disease chronicity in experimental
arthritis has included a new focus on the draining lymph node (LN). Here, we combined …

Lymph draining from foot joints in rheumatoid arthritis provides insight into local cytokine and chemokine production and transport to lymph nodes

WL Olszewski, J Pazdur, E Kubasiewicz… - Arthritis & …, 2001 - Wiley Online Library
Objective Rheumatoid arthritis (RA) is characterized by inflammatory reactions in joints and
adjacent tissues unaccompanied by clinically evident changes in lymphatics and lymph …