Publisher Summary This chapter discusses the inactivation of intracellular Rho to stimulate
axon growth and regeneration. In tissue culture, inactivation of the Rho signaling pathway is …

Publisher Summary This chapter describes Rho guanosine 5'-triphosphates (GTPases) and
axonal growth cone collapse. The axonal growth cone is the specialized distal tip of the …

The regeneration of adult peripheral neurons after transection is slow, incomplete and
encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been …

Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is
believed that the capacities of neurons to regrow their axons are due partly to their intrinsic …

Neurons in the adult mammalian CNS do not spontaneously regenerate axons after injury
due to CNS myelin and other inhibitory factors. Previous studies have showed that inhibition …

Several major advances in our understanding of axon regeneration and functional repair in
the central nervous system (CNS) together with new insights about molecular signaling …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Abstract The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK)
pathway is a major signaling pathway in the central nervous system, transducing inhibitory …

The activation state of Rho is an important determinant of axon growth and regeneration in
neurons. Axons can extend neurites on growth inhibitory substrates when Rho is inactivated …

Many external signals influence growth cone motility, pathfinding, and the formation of
synapses that lead to the final map formation of the retinotectal system. Chick temporal …