Genomic characterization of Imipenem-and Imipenem-Relebactam-Resistant clinical isolates of pseudomonas aeruginosa

M López-Pérez, JM Haro-Moreno, C Molina-Pardines… - Msphere, 2021 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen and a major cause of
nosocomial infections. The global spread of carbapenem-resistant strains is growing rapidly …

Genomic surveillance of clinical Pseudomonas aeruginosa isolates reveals an additive effect of carbapenemase production on carbapenem resistance

L Diorio-Toth, S Irum, RF Potter, MA Wallace… - Microbiology …, 2022 - Am Soc Microbiol
Carbapenem resistance in Pseudomonas aeruginosa is increasing globally, and
surveillance to define the mechanisms of such resistance in low-and middle-income …

[HTML][HTML] Characterization of Pseudomonas aeruginosa with discrepant carbapenem susceptibility profile

AK Pragasam, M Raghanivedha, S Anandan… - Annals of clinical …, 2016 - Springer
Pseudomonas aeruginosa is the most common nosocomial pathogen, notorious for its
multidrug resistance and causes life threatening infections. Carbapenems were considered …

Genomewide Identification of Genetic Determinants of Antimicrobial Drug Resistance in Pseudomonas aeruginosa

A Dötsch, T Becker, C Pommerenke… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The emergence of antimicrobial drug resistance is of enormous public concern due to the
increased risk of delayed treatment of infections, the increased length of hospital stays, the …

The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility

VN Kos, M Déraspe, RE McLaughlin… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Many clinical isolates of Pseudomonas aeruginosa cause infections that are difficult to
eradicate due to their resistance to a wide variety of antibiotics. Key genetic determinants of …

A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas …

SJT Wardell, A Rehman, LW Martin… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute
and chronic infections. An increasing number of isolates have mutations that make them …

Complexity of resistance mechanisms to imipenem in intensive care unit strains of Pseudomonas aeruginosa

D Fournier, C Richardot, E Müller… - Journal of …, 2013 - academic.oup.com
Background Pseudomonas aeruginosa can become resistant to carbapenems by both
intrinsic (mutation-driven) and transferable (β-lactamase-based) mechanisms. Knowledge of …

[HTML][HTML] Mechanisms for Rapid Evolution of Carbapenem Resistance in a Clinical Isolate of Pseudomonas aeruginosa

C Xu, D Wang, X Zhang, H Liu, G Zhu, T Wang… - Frontiers in …, 2020 - frontiersin.org
Infections by Pseudomonas aeruginosa are difficult to cure due to its high intrinsic and
acquired antibiotic resistance. Once colonized the human host, and thanks to antibiotic …

[HTML][HTML] The Versatile Mutational Resistome of Pseudomonas aeruginosa

C López-Causapé, G Cabot… - Frontiers in …, 2018 - frontiersin.org
One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for
developing antimicrobial resistance to nearly all available antipseudomonal agents through …

Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant Pseudomonas aeruginosa

J Janice, N Agyepong, A Owusu-Ofori… - Antimicrobial agents …, 2021 - Am Soc Microbiol
Two novel bla DIM-1-or bla IMP-1-containing genomic islands (GIs) were discovered by
whole-genome sequence analyses in four extensively drug-resistant (XDR) Pseudomonas …