Tumor penetrating peptides for improved drug delivery

E Ruoslahti - Advanced drug delivery reviews, 2017 - Elsevier
In vivo screening of phage libraries in tumor-bearing mice has been used to identify
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …

Applications of cell-penetrating peptides for tumor targeting and future cancer therapies

J Regberg, A Srimanee, Ü Langel - Pharmaceuticals, 2012 - mdpi.com
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery.
One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide …

Peptide and protein drug delivery to and into tumors: challenges and solutions

VP Torchilin, AN Lukyanov - Drug discovery today, 2003 - Elsevier
The potential of peptide and protein anticancer agents has yet to be realized owing to the
many unresolved problems concerning their delivery to the site of a tumor and into tumor …

Tumor-penetrating peptides

T Teesalu, KN Sugahara, E Ruoslahti - Frontiers in oncology, 2013 - frontiersin.org
Tumor-homing peptides can be used to deliver drugs into tumors. Phage library screening in
live mice has recently identified homing peptides that specifically recognize the endothelium …

Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides

S Dissanayake, WA Denny, S Gamage… - Journal of Controlled …, 2017 - Elsevier
Efficient intracellular trafficking and targeted delivery to the site of action are essential to
overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) …

Selective targeting of cancer cells using synthetic peptides

M Shadidi, M Sioud - Drug Resistance Updates, 2003 - Elsevier
To establish efficient and reliable therapeutic delivery into cancer cells, a number of delivery
agents and concepts have been investigated in the recent years. Among many …

Cell-penetrating peptides transport therapeutics into cells

JD Ramsey, NH Flynn - Pharmacology & therapeutics, 2015 - Elsevier
Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

[HTML][HTML] Cell penetrating peptides in preclinical and clinical cancer diagnosis and therapy

PP Tripathi, H Arami, I Banga, J Gupta, S Gandhi - Oncotarget, 2018 - ncbi.nlm.nih.gov
Delivery of imaging reagents and drugs to tumors is essential for cancer diagnosis and
therapy. In addition to therapeutic and diagnostic functionalities, peptides have potential …

Peptide-based targeted therapeutics: Focus on cancer treatment

F Araste, K Abnous, M Hashemi, SM Taghdisi… - Journal of controlled …, 2018 - Elsevier
Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …

Enzyme-triggered, cell penetrating peptide-mediated delivery of anti-tumor agents

H He, L Sun, J Ye, E Liu, S Chen, Q Liang… - Journal of Controlled …, 2016 - Elsevier
Conventional chemotherapy has little or no specificity for cancer cells, normally resulting in
low drug accumulation at the tumor region (inefficacy) and drug-induced severe side effects …