The use of combinations of inexpensive drugs for the treatment of malaria in Africa has been
proposed as an interim policy while awaiting the widespread availability of more effective …

Background Opinion and policy over the use of amodiaquine for treating malaria vary.
Amodiaquine is more palatable than chloroquine and may be more effective but serious …

Background Plasmodium falciparum resistance has rendered chloroquine monotherapy
ineffective in much of Africa, but data on alternative regimens are limited. We compared …

Summary Background Increasing Plasmodium falciparum resistance to chloroquine in sub-
Saharan Africa necessitates use of alternative antimalarial agents. Affordable alternative …

Background Artemether‐lumefantrine is being recommended by the World Health
Organization for treating uncomplicated malaria. It is expensive. We sought evidence of its …

Background Many conventional treatments for uncomplicated malaria are failing because
malaria parasites develop resistance to them. One way to combat this resistance is to treat …

In a southern border province of Lao PDR, we compared the efficacy of antimalarial drug
combinations in patients aged≥ 1 year with uncomplicated Plasmodium falciparum malaria …

Background Given increasing rates of resistance to existing therapy, new options for
treatment and prophylaxis of malaria are needed. Methods Two randomised, comparative …

Background In Malawi, there has been a return of Plasmodium falciparum sensitivity to
chloroquine (CQ) since sulfadoxine-pyrimethamine (SP) replaced CQ as first line treatment …

Objectives In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-
pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by …