The efficacy of pyrimethamine/sulfadoxine (PS) and chloroquine plus chlorpheniramine, a
histamine H1 receptor blocker which reverses chloroquine insensitivity in Plasmodium …

Background Malaria is an important cause of morbidity and mortality, in particular among
children and pregnant women in sub‐Saharan Africa. Prompt access to diagnosis and …

Chloroquine (CQ) remains the first-line treatment for uncomplicated malaria in much of
Africa despite the growing problem of resistance to this drug. Sulfadoxine-pyrimethamine …

Background To explore the use of azithromycin–chloroquine (AZCQ) for the treatment of
malaria, we conducted double-blind, randomized, non-inferiority studies in India, Colombia …

The safety and the efficacy of amodiaquine (AQ) alone, AQ plus sulfadoxine-pyrimethamine
(SP)(AQ plus SP), and artesunate (ART) plus SP (ART plus SP), three possible alternatives …

We conducted a double-blind, randomized, placebo-controlled trial in Sao Tome and
Principe to investigate the safety, tolerability and efficacy of chloroquine (CQ) combined with …

Malaria remains an important cause of illness and death in children and adults in countries
in which it is endemic. Malaria control requires an integrated approach including prevention …

A major problem in the control of malaria is the development of resistance, of the parasites to
the existing drugs and of the vectors to insecticides. With few new drugs in the pipeline, in an …

Background The WHO recommends artemisinin-based combination therapies (ACTs) for the
treatment of uncomplicated falciparum malaria. Hence, monitoring the efficacy of …

Systematic database searches identified 435 antimalarial drug treatment trials, involving 82
616 patients, conducted and published between 1966 and December 2002. Of these trials …