Purpose Wuzhi capsule (WZ) is a proprietary Chinese medicine prepared from the ethanolic
extract of Schisandra sphenanthera that is commonly used to treat liver injury. Statins are …

The effect of breviscapine injection on the pharmacokinetics of simvastatin and the mRNA
expression of hepatic cytochrome P450 (CYP) enzyme was investigated with rats. The rats …

Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats
was evaluated. To ensure the accuracy of the results, a rapid and sensitive UPLC–MS/MS …

Schisandrae has a long history of medicinal use in China. Domestic and foreign scholars
have isolated a variety of chemical constituents from Schisandrae Sphenantherae Fructus …

Background It has been demonstrated that acute oral administration of schisandrin B (Sch
B), an active dibenzocyclooctadiene isolated from Schisandrae Fructus (a commonly used …

The aim of this study was to explore potential herb–drug interaction between danshensu or
ursolic acid and rosuvastatin. Compared to the control group given rosuvastatin alone, the …

The effects of schisandrin B (Sch B) on liver and serum lipid contents were investigated in
mice with experimentally‐induced hypercholesterolaemia. Hypercholesterolaemia was …

Objective St John's Wort, a widely used herbal product, is an inducer of CYP3A4 and it
decreases blood concentrations of CYP3A4 substrates. The effects of St John's Wort on the …

Abstract Ethnopharmacological relevance Fructus Schisandrae is traditionally used as a
liver-toning Chinese herb. Recent studies suggested Fructus Schisandrae could prevent …

Schisandra is the mature fruit of Schisandra chinensis (known as" north Schisandra") or S.
shenanthera (known as" south Schisandra"). S. chinensis contains a variety of lignans …