Objectives Platelets generate oxidized LDL (ox-LDL) via NOX2-derived oxidative stress. We
investigated if once generated by activated platelets ox-LDL can propagate platelet …

Objective—Because of the large variation in oxidizing procedures and susceptibility to
oxidation of low-density lipoprotein (LDL) and the lack in quantification of LDL oxidation, the …

Objective—The interaction of platelets with low density lipoprotein (LDL) contributes to the
development of cardiovascular disease. Platelets are activated by native LDL (nLDL) …

Oxidative stress‐mediated LDL modification has a key role in initiation of the atherosclerotic
process. Platelets produce reactive oxidant species (ROS) upon stimulation with agonist, but …

Native LDL and LDL oxidized under various conditions were compared in terms of their
ability to activate platelets. Native LDL did not induce platelet shape change or aggregation …

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in
dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how …

Platelets are involved in the initiation of atherosclerosis by adherence to inflamed
endothelium. Monocytes bind to these platelets and transmigrate into the vessel wall …

Atherosclerosis and its complications, including acute coronary syndromes, are the major
cause of death worldwide. The two most important pathophysiological mechanisms …

Hydroxymethyl-glutaryl-CoA-reductase inhibitors (statins) reduce cardiovascular mortality by
decreasing cholesterol as well as by non-lipid-related actions. Oxidized low-density …

Background Oxidized LDL (ox-LDL) promotes vasoconstriction and platelet activation. The
present study was undertaken to determine the involvement of the l-arginine–nitric oxide …