Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway

Y Ding, Y Wang, Y Zhang, B Dang, S Hu, C Zhao… - Phytomedicine, 2023 - Elsevier
Background Allergic rhinitis (AR) defined as inflammation and tissue remodeling of the nasal
mucosa in atopic individuals after allergen exposure. Alpha-linolenic acid [cis-9, cis-12, cis …

[HTML][HTML] α-linolenic acid screened by molecular docking attenuates inflammation by regulating Th1/Th2 imbalance in ovalbumin-induced mice of allergic rhinitis

M Ren, Y Wang, L Lin, S Li, Q Ma - Molecules, 2022 - mdpi.com
α-Linolenic acid (ALA) is a natural essential fatty acid widely found in plant seed oils and
beans, which shows positive anti-inflammatory and antiallergic effects. In our previous study …

[HTML][HTML] Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling

T Van Nguyen, CH Piao, YJ Fan, DU Shin, SY Kim… - Scientific Reports, 2020 - nature.com
An ovalbumin (OVA)-induced allergic rhinitis (AR) mouse model was established to
investigate whether α-Lipoic acid (LA) has a protective effect against upper respiratory tract …

Gallic acid alleviates nasal inflammation via activation of Th1 and inhibition of Th2 and Th17 in a mouse model of allergic rhinitis

Y Fan, CH Piao, E Hyeon, SY Jung, JE Eom… - International …, 2019 - Elsevier
Allergic rhinitis (AR) is an allergic nasal disease characterized by nasal obstruction,
rhinorrhea, sneezing, and itching. Type 1 helper T cells (Th1)/type 2 helper T cells (Th2) …

Cang-ai volatile oil alleviates nasal inflammation via Th1/Th2 cell imbalance regulation in a rat model of ovalbumin-induced allergic rhinitis

Y Zhou, B Chen, Y Fu, C Wan, H Li, L Wang… - Frontiers in …, 2024 - frontiersin.org
We previously revealed that Cang-ai volatile oil (CAVO) regulates T-cell activity, enhancing
the immune response in people with chronic respiratory diseases. However, the effects of …

[HTML][HTML] Xiao-qing-long-tang ameliorates OVA-induced allergic rhinitis by inhibiting ILC2s through the IL-33/ST2 and JAK/STAT pathways

J Zhang, X He, M Zhou, Q Liu, W Xu, Y Yan, Y Ruan - Phytomedicine, 2023 - Elsevier
Background Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa that
is mediated by immunoglobulin E (IgE). Xiao-qing-long-tang (XQLT) is a traditional Chinese …

Sinapic acid ameliorates airway inflammation in murine ovalbumin-induced allergic asthma by reducing Th2 cytokine production

M Saeedavi, M Goudarzi, S Mehrzadi, Z Basir… - Life Sciences, 2022 - Elsevier
Objective Asthma is a chronic inflammatory airway disease associated with the airway
narrowing and obstruction. Sinapic acid (SA), a hydroxycinnamic acid, possesses various …

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats

MH Boskabady, M Kaveh, F Shakeri… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)-induced
inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat …

Gallic acid attenuates allergic airway inflammation via suppressed interleukin‐33 and group 2 innate lymphoid cells in ovalbumin‐induced asthma in mice

X Wang, H Zhao, C Ma, L Lv, J Feng… - International Forum of …, 2018 - Wiley Online Library
Background Asthma is an inflammatory disease characterized by airway
hyperresponsiveness. Gallic acid is a powerful anti‐inflammatory agent. In this study we …

[HTML][HTML] The extract of black cumin, licorice, anise, and black tea alleviates OVA-induced allergic rhinitis in mouse via balancing activity of helper T cells in lung

C Liao, Y Han, Z Chen, H Baigude - Allergy, Asthma & Clinical Immunology, 2021 - Springer
Background A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.),
anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze)(denoted BLAB tea) is …