[HTML][HTML] Immunopharmacology of post-myocardial infarction and heart failure medications

M Panahi, N Vadgama, M Kuganesan, FS Ng… - Journal of Clinical …, 2018 - mdpi.com
The immune system responds to acute tissue damage after myocardial infarction (MI) and
orchestrates healing and recovery of the heart. However, excessive inflammation may lead …

Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition

M Panahi, A Papanikolaou, A Torabi… - Cardiovascular …, 2018 - academic.oup.com
Following a myocardial infarction (MI), the immune system helps to repair ischaemic
damage and restore tissue integrity, but excessive inflammation has been implicated in …

[HTML][HTML] Post-ischemic myocardial inflammatory response: a complex and dynamic process susceptible to immunomodulatory therapies

NJ Pluijmert, DE Atsma, PHA Quax - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …

[HTML][HTML] Immune cells drive new immunomodulatory therapies for myocardial infarction: From basic to clinical translation

W Nian, Z Huang, C Fu - Frontiers in Immunology, 2023 - frontiersin.org
The high incidence of heart failure secondary to myocardial infarction (MI) has been difficult
to effectively address. MI causes strong aseptic inflammation, and infiltration of different …

Immunomodulation and immunopharmacology in heart failure

G Markousis-Mavrogenis, L Baumhove… - Nature Reviews …, 2024 - nature.com
The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …

Mechanisms of cardioprotection via modulation of the immune response

GA Grilo, PR Shaver, LE de Castro Brás - Current Opinion in Pharmacology, 2017 - Elsevier
Highlights•Current research focus on cardioprotective immune-targeted therapeutic
approaches.•Ischemic preconditioning is a powerful cardioprotective treatment.•The immune …

[HTML][HTML] The role of immune cells in cardiac remodeling after myocardial infarction

Y Zhang, W Wen, H Liu - Journal of cardiovascular pharmacology, 2020 - journals.lww.com
Myocardial infarction (MI) is an irreversible damage of the heart muscle, which often leads to
adverse cardiac remodeling and progressive heart failure. After MI, immune cells play a vital …

Autoimmunity in myocardial infarction

YH Liao, X Cheng - International journal of cardiology, 2006 - Elsevier
Myocardial infarction is associated with an immune response. Physiological inflammation
response causes self-repair and protection, while pathological autoimmune response leads …

The cardiac injury immune response as a target for regenerative and cellular therapies

RD Hume, JJH Chong - Clinical Therapeutics, 2020 - Elsevier
Purpose Despite modern reperfusion and pharmacologic therapies, myocardial infarction
(MI) remains a leading cause of morbidity and mortality worldwide. Therefore, the …

[HTML][HTML] Innate immune receptors in heart failure: Side effect or potential therapeutic target?

KB Wagner, SB Felix, A Riad - World journal of cardiology, 2014 - ncbi.nlm.nih.gov
Heart failure (HF) is a leading cause of mortality and morbidity in western countries and
occasions major expenses for public health systems. Although optimal medical treatment is …