Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Genome-wide expression and methylation profiling reveal candidate genes in osteoarthritis
Page 1 Clinical and Experimental Rheumatology 2017 Clinical and Experimental …

The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being
obesity, age, environmental variables, and genetic predisposition. The available evidence …

Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of
disease-modifying drugs resulting, to a significant degree, from our incomplete …

Osteoarthritis (OA) is a disease typified by the loss of cartilage, the normal integrity of which
is maintained by the resident cell, the chondrocyte. Alterations in chondrocyte gene …

Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …

Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …