DNA methylation and noncoding RNA in OA: Recent findings and methodological advances
V Izda, J Martin, C Sturdy, MA Jeffries - Osteoarthritis and cartilage open, 2021 - Elsevier
Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …
progressive loss of joint function. Historically, it has been characterized as a disease caused …
[HTML][HTML] DNA methylation in osteoarthritis: current status and therapeutic implications
A Miranda-Duarte - The open rheumatology journal, 2018 - ncbi.nlm.nih.gov
Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …
are strongly associated with its development; however, recently it has been observed that …
[HTML][HTML] Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease?
LN Reynard - Seminars in Cell & Developmental Biology, 2017 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …
[PDF][PDF] Genome-wide expression and methylation profiling reveal candidate genes in osteoarthritis
Y Fan, J Chen, Y Yang, J Lin, Z Wu - Clin Exp Rheumatol, 2017 - clinexprheumatol.org
Genome-wide expression and methylation profiling reveal candidate genes in osteoarthritis
Page 1 Clinical and Experimental Rheumatology 2017 Clinical and Experimental …
Page 1 Clinical and Experimental Rheumatology 2017 Clinical and Experimental …
DNA methylation as a mediator of epigenetic regulation in the pathogenesis and precision medicine of osteoarthritis: An updated review.
Q Zhou, J Liu, L Xin, Y Fang, L Wan, D Huang… - …, 2023 - search.ebscohost.com
The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being
obesity, age, environmental variables, and genetic predisposition. The available evidence …
obesity, age, environmental variables, and genetic predisposition. The available evidence …
The first international workshop on the epigenetics of osteoarthritis
IM Meulenbelt, N Bhutani, W den Hollander… - Connective tissue …, 2017 - Taylor & Francis
Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of
disease-modifying drugs resulting, to a significant degree, from our incomplete …
disease-modifying drugs resulting, to a significant degree, from our incomplete …
Epigenetic mechanisms and non-coding RNAs in osteoarthritis
Osteoarthritis (OA) is a disease typified by the loss of cartilage, the normal integrity of which
is maintained by the resident cell, the chondrocyte. Alterations in chondrocyte gene …
is maintained by the resident cell, the chondrocyte. Alterations in chondrocyte gene …
Analysis of methylation datasets identified significantly changed genes and functional pathways in osteoarthritis
B Han, Z Zheng, J Ren, W Qiu, X Li - Clinical Rheumatology, 2019 - Springer
Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …
The epigenomic landscape in osteoarthritis
TC Simon, MA Jeffries - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients
J Fernández-Tajes, A Soto-Hermida… - Annals of the …, 2014 - ard.bmj.com
Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …