Arterial hypertension causes left ventricular (LV) myocyte hypertrophy. Alterations in nuclear
Ca 2+ may be involved in regulation of histone acetylation, transcription and hypertrophy …

Background—A hallmark of heart failure is impaired cytoplasmic Ca2+ handling of
cardiomyocytes. It remains unknown whether specific alterations in nuclear Ca2+ handling …

In the heart, cytosolic Ca2+ signals are well-characterized events that participate in the
activation of cell contraction. In contrast, nuclear Ca2+ contribution to cardiomyocyte function …

Ca2+ signaling through CaMKII is critical in regulating myocyte function with regard to
excitation–contraction–relaxation cycles and excitation–transcription coupling. To …

In cardiomyocytes, nuclear calcium is involved in regulation of transcription and, thus,
remodeling. The cellular mechanisms regulating nuclear calcium, however, remain elusive …

Age and hypertension contribute significantly to cardiac morbidity and mortality, however the
importance of each during the progression of hypertrophy is unclear. This investigation …

Calcium (Ca 2+) is a universal second messenger involved in the regulation of various
cellular processes, including electrical signaling, contraction, secretion, memory, gene …

Class II histone deacetylases (HDACs) act as repressors of cardiac hypertrophy, an
adaptative response of the heart characterized by a reprogramming of fetal cardiac genes …

The use of confocal microscopy has shown that the nucleus plays an important role in
excitation–contraction and excitation–secretion coupling of several excitable and …

Rationale: CaMKII (Ca2+-Calmodulin dependent protein kinase) δC activation is implicated
in pathological progression of heart failure (HF) and CaMKIIδC transgenic mice rapidly …