Previously, our comprehensive cardiovascular characterization study validated Uromodulin
as a blood pressure gene. Uromodulin is a glycoprotein exclusively synthesized at the thick …

Salt sensitivity impacts a significant portion of the population and is an important contributor
to the development of chronic kidney disease. One of the significant early predictors of salt …

A recent genome-wide association study identified a locus on chromosome 16 in the
promoter region of the uromodulin (UMOD) gene that is associated with hypertension. Here …

Hypertension is a prevalent disorder in the world representing one of the major risk factors
for heart attack and stroke. These risks are increased in salt sensitive individuals …

In the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hyponatremia is
limited by onset of vasopressin-escape caused by loss of the water channel aquaporin-2 in …

In the distal kidney tubule, the steroid hormone aldosterone regulates sodium reabsorption
via the epithelial sodium channel (ENaC). Most studies seeking to identify ENaC-regulating …

High salt diet (HSD) is a hallmark of blood pressure elevations, weight gain and diabetes
onset in the metabolic syndrome. In kidney, compensatory mechanisms are activated to …

Revisiting sodium and water reabsorption with functional gen... : Current Opinion in Nephrology
and Hypertension Revisiting sodium and water reabsorption with functional genomics tools …

Background Renal endothelial cells from glomerular, cortical, and medullary kidney
compartments are exposed to different microenvironmental conditions and support specific …

Background The changes in the renal function leading to a reduction of medullary blood flow
can have a great impact on sodium and water homeostasis and on the long-term control of …