Bone cancer pain has a strong impact on the quality of life of patients but is difficult to treat.
Therefore, the mechanisms of bone cancer pain require elucidation for the purpose of …

Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent
of pain. Inspiring achievements have been made in the characterization of itch-related …

Recent studies have demonstrated that the lipopolysaccharide (LPS) receptor (TLR4) is
expressed in TRPV1 containing trigeminal sensory neurons. In this study, we evaluated …

Odontoblasts form the outermost cellular layer of the dental pulp where they have been
proposed to act as sensory receptor cells. Despite this suggestion, evidence supporting their …

Although xerostomia can cause persistent oral pain, the mechanisms underlying such pain
are not well understood. To evaluate whether a phosphorylated p38 (pp38)-TRPV4 …

According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal
fluid movement following the application of various stimuli to the dentin surface. Recent …

Background Morphine and its derivatives are key drugs in pain control. Despite its well-
known analgesic properties morphine at high concentrations may be proalgesic …

A study was conducted to evaluate the mechanisms underlying ectopic orofacial pain
associated with tooth pulp inflammation in rats. We observed a significant decrease in the …

Background Transient receptor potential (TRP) cation channels are involved in the
perception of hot and cold pain and are targets for pain relief in humans. We hypothesized …

The tooth has an unusual sensory system that converts external stimuli predominantly into
pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non …