HLA class II expression by Hodgkin Reed-Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma

A Diepstra, GW van Imhoff, HE Karim-Kos… - Journal of clinical …, 2007 - ascopubs.org
Purpose The neoplastic Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin's
lymphoma (cHL) are derived from B cells. The frequency of HLA class II downregulation and …

Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: a clinicopathologic study

N Asano, A Oshiro, K Matsuo, Y Kagami… - Journal of clinical …, 2006 - ascopubs.org
Purpose Classical Hodgkin's lymphoma (CHL) is characterized by Hodgkin's and Reed-
Sternberg (H-RS) cells, most of which are derived from germinal-center B cells …

HLA associations in classical Hodgkin lymphoma: EBV status matters

X Huang, K Kushekhar, I Nolte, W Kooistra, L Visser… - PloS one, 2012 - journals.plos.org
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic
factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a …

Hodgkin lymphoma: pathology and biology

S Mathas, S Hartmann, R Küppers - Seminars in hematology, 2016 - Elsevier
Abstract The Hodgkin and Reed-Sternberg (HRS) tumor cells of classical Hodgkin
lymphoma (HL), as well as the lymphocyte predominant (LP) cells of nodular lymphocyte …

The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate …

M Niens, A Van Den Berg, A Diepstra, IM Nolte… - … Biomarkers & Prevention, 2006 - AACR
Various studies have indicated that the human leukocyte antigen (HLA) region is associated
with Hodgkin's lymphoma. We recently showed a specific association of the HLA class I …

Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance …

A Bräuninger, HH Wacker, K Rajewsky, R Küppers… - Cancer research, 2003 - AACR
Hodgkin′ s lymphoma (HL) is separated into the classical (c) and lymphocyte-
predominance (lp) forms. Whereas classical Hodgkin-Reed/Sternberg (HRS) cells carry …

Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival

G Venkataraman, JY Song, A Tzankov… - Blood, The Journal …, 2013 - ashpublications.org
Abstract Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) rarely
express T-cell-associated antigens (TCA), but the clinical significance of this finding is …

Hodgkin lymphoma: a review of pathological features and recent advances in pathogenesis

MA Piris, LJ Medeiros, KC Chang - Pathology, 2020 - Elsevier
Hodgkin lymphoma (HL) is composed of two distinct pathological entities, nodular
lymphocyte predominant HL and classic HL, the latter with four subtypes. In contrast with …

Pathobiology of classical Hodgkin lymphoma

A Tzankov, S Dirnhofer - Pathobiology, 2006 - karger.com
Abstract The World Health Organization has acknowledged the malignant nature of classical
Hodgkin lymphoma (cHL), which encompasses four histological subtypes. The diagnosis of …

Pathogenesis of Hodgkin's lymphoma

R Küppers, R Schmitz, V Distler… - European Journal of …, 2005 - Wiley Online Library
In Hodgkin's lymphoma (HL), the B cell origin of the tumour cells, the Hodgkin and Reed‐
Sternberg (HRS) cells, has been disclosed by molecular single cell analysis about 10 yr …