The transcription factor Pax6 is considered the master control gene for eye formation
because (1) it is present within the genomes and retina/lens of all animals with a visual …

The Pax-6 gene encodes a transcription factor with two DNA-binding domains, a paired and
a homeodomain, and is expressed during eye morphogenesis and development of the …

Paired box 6 (Pax6) is considered to be the master control gene for eye development in all
seeing animals studied so far. In vertebrates, it is required not only for lens/retina formation …

We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus
laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers …

Pax-6 genes, known to be essential for eye development, encode an evolutionarily
conserved transcription factor with two DNA-binding domains. To corroborate the …

We report the identification of a Drosophila Pax gene, eye gone (eyg), which is required for
eye development. Loss-of-function eyg mutations cause reduction or absence of the eye …

The discovery that Drosophilaeyeless is homologous to vertebrate Pax6 produced
enormous interest in eye specification and a reappraisal of eye evolution. While the …

Pax genes encode DNA binding proteins that play pivotal roles in the determination of
complex tissues. Members of one subclass, Pax6, function as selector genes and play key …

Abstract The Drosophila Pax-6 gene eyeless (ey) plays a key role in eye development. Here
we show that Drosophila contains a second Pax-6 gene, twin of eyeless (toy), due to a …

Loss of Pax 6 function leads to an eyeless phenotype in both mammals and insects, and
ectopic expression of both the Drosophila and the mouse gene leads to the induction of …