Atopic dermatitis endotypes based on allergen sensitization, reactivity to Staphylococcus aureus antigens, and underlying systemic inflammation

A Leonard, J Wang, L Yu, H Liu, Y Estrada… - The Journal of Allergy …, 2020 - Elsevier
Background Atopic dermatitis (AD) is a chronic inflammatory disease with significant local
and systemic inflammation and barrier disruption. AD is associated with increased risk of …

Moving toward endotypes in atopic dermatitis: identification of patient clusters based on serum biomarker analysis

JL Thijs, I Strickland, CAFM Bruijnzeel-Koomen… - Journal of Allergy and …, 2017 - Elsevier
Background Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease with a
diverse clinical presentation. However, it is unclear whether this diversity exists at a …

Phenotypic and endotypic determinants of atopic dermatitis severity from the Atopic Dermatitis Research Network (ADRN) Registry

EL Simpson, A De Benedetto, M Boguniewicz… - The Journal of Allergy …, 2023 - Elsevier
Background Atopic dermatitis (AD) is a chronic inflammatory skin condition with a highly
variable clinical phenotype. Objective This study aimed to identify historical and clinical …

Atopic dermatitis stratification: current and future perspective on skin and blood transcriptomic and proteomic profiling

K Hawkins, E David, JW Glickman… - Expert Review of …, 2024 - Taylor & Francis
Introduction Atopic dermatitis (AD) is a common, chronic inflammatory skin disorder driven
by an intricate interplay of genetic, environmental, and immunological factors. Areas covered …

Recent insights into comorbidities in atopic dermatitis

C Gewiss, M Augustin - Expert Review of Clinical Immunology, 2023 - Taylor & Francis
Introduction The relationship between atopic dermatitis and atopic diseases such as food
allergies, asthma, and allergic rhinitis in terms of co-occurrence, underlying mechanisms …

Transcriptome‐based identification of novel endotypes in adult atopic dermatitis

A Lefèvre‐Utile, M Saichi, P Oláh, M Delord, B Homey… - Allergy, 2022 - Wiley Online Library
Background Atopic dermatitis (AD) is a frequent and heterogeneous inflammatory skin
disease, for which personalized medicine remains a challenge. High‐throughput …

IgE sensitization profiles differ between adult patients with severe and moderate atopic dermatitis

I Mittermann, G Wikberg, C Johansson, C Lupinek… - PloS one, 2016 - journals.plos.org
Background Atopic dermatitis (AD) is a complex chronic inflammatory disease where
allergens can act as specific triggering factors. Aim To characterize the specificities of IgE …

[HTML][HTML] Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

DS Bakker, S Nierkens, EF Knol, B Giovannone… - Journal of Allergy and …, 2021 - Elsevier
Background Atopic dermatitis (AD) is a highly heterogeneous disease, both clinically and
biologically, whereas patients are still being treated according to a “one-size-fits-all” …

Atopic dermatitis: striving for reliable biomarkers

S Mastraftsi, G Vrioni, M Bakakis, E Nicolaidou… - Journal of Clinical …, 2022 - mdpi.com
Atopic dermatitis (AD) is a highly heterogeneous inflammatory disease regarding both its
pathophysiology and clinical manifestations. However, it is treated according to the “one …

The relevance of microbial allergens to the IgE antibody repertoire in atopic and nonatopic eczema

AJ Reefer, SM Satinover, BB Wilson… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: A propensity to microbial skin infections has been reported in atopic (“high
IgE”) and nonatopic (“low IgE”) forms of eczema. However, the relationship between …