The acquisition of iron from mammalian hosts is an important aspect of infection because
microbes must compete with the host for this nutrient and iron perception often regulates …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …

Iron acquisition is critical for the ability of the pathogenic yeast Cryptococcus neoformans to
cause disease in vertebrate hosts. In particular, iron overload exacerbates cryptococcal …

Cryptococcus neoformans is the leading cause of fungal meningitis in humans. Production
of a polysaccharide capsule is a key virulence property for the fungus and capsule synthesis …

Iron acquisition is a critical aspect of the virulence of many pathogenic microbes, and iron
limitation is an important defense mechanism for mammalian hosts. We are examining …

Iron availability is a key regulator of virulence factor elaboration in Cryptococcus
neoformans, the causative agent of fungal meningoencephalitis in HIV/AIDS patients. In …

Iron overload is known to exacerbate many infectious diseases, and conversely, iron
withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for …

The GATA-type, zinc-finger protein Cir1 regulates iron uptake, iron homeostasis and
virulence factor expression in the fungal pathogen Cryptococcus neoformans. The …

The mechanisms by which pathogens sense and transport iron are important during
infection, because of the low availability of free iron in the mammalian host. Iron is a key …