Fifty Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value

JG Laffey, MA Matthay - American journal of respiratory and critical …, 2017 - atsjournals.org
On the basis of several preclinical studies, cell-based therapy has emerged as a potential
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …

Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome

M Lopes-Pacheco, C Robba, PRM Rocco… - Cell biology and …, 2020 - Springer
The acute respiratory distress syndrome (ARDS) is a multifaceted lung disorder in which no
specific therapeutic intervention is able to effectively improve clinical outcomes. Despite an …

[HTML][HTML] Cell therapy in acute respiratory distress syndrome

S Horie, HE Gonzalez, JG Laffey… - Journal of thoracic …, 2018 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is driven by a severe pro-inflammatory
response resulting in lung damage, impaired gas exchange and severe respiratory failure …

Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors

JW Lee, X Fang, A Krasnodembskaya, JP Howard… - Stem …, 2011 - academic.oup.com
Morbidity and mortality have declined only modestly in patients with clinical acute lung injury
(ALI) and acute respiratory distress syndrome (ARDS), despite extensive research into the …

Genetically modified mesenchymal stem cell therapy for acute respiratory distress syndrome

J Han, Y Liu, H Liu, Y Li - Stem Cell Research & Therapy, 2019 - Springer
Acute respiratory distress syndrome (ARDS) is a devastating hypoxemic respiratory failure,
characterized by disruption of the alveolar-capillary membrane barrier. Current management …

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

JG Wilson, KD Liu, H Zhuo, L Caballero… - The Lancet …, 2015 - thelancet.com
Background No effective pharmacotherapy for acute respiratory distress syndrome (ARDS)
exists, and mortality remains high. Preclinical studies support the efficacy of mesenchymal …

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis

J Walter, LB Ware, MA Matthay - The Lancet Respiratory Medicine, 2014 - thelancet.com
Multipotent mesenchymal stem (stromal) cells (MSCs) have shown promising therapeutic
effects in preclinical models of both acute respiratory distress syndrome (ARDS) and sepsis …

Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome-hope or hype?

M Hayes, G Curley, B Ansari, JG Laffey - Critical Care, 2012 - Springer
A growing understanding of the complexity of the pathophysiology of acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS), coupled with advances in stem cell …

Mesenchymal stem cells from bone marrow, adipose tissue, and lung tissue differentially mitigate lung and distal organ damage in experimental acute respiratory …

JD Silva, M Lopes-Pacheco, AHR Paz… - Critical care …, 2018 - journals.lww.com
Objectives: Mesenchymal stem cells–based therapies have shown promising effects in
experimental acute respiratory distress syndrome. Different mesenchymal stem cells …

Potential application of mesenchymal stem cells in acute lung injury

JW Lee, N Gupta, V Serikov… - Expert opinion on …, 2009 - Taylor & Francis
Despite extensive research into the pathogenesis of acute lung injury and the acute
respiratory distress syndrome (ALI/ARDS), mortality remains high at approximately 40 …