Aims Phospholamban (PLB) is the key regulator of the cardiac Ca 2+ pump (SERCA2a)-
mediated sarcoplasmic reticulum Ca 2+ stores. We recently reported that PLB is highly …

Aims Phospholamban (PLB) regulates the cardiac Ca 2+-ATPase (SERCA2a) in
sarcoplasmic reticulum (SR). However, the localization of PLB at subcellular sites outside …

Aims Phospholamban (PLB) stoichiometrically regulates the cardiac Ca 2+ pump
(SERCA2a) in the sarcoplasmic reticulum (SR); but in the nuclear envelope (NE) of …

Phospholamban (PLB) inhibits the activity of cardiac sarcoplasmic reticulum (SR) Ca 2+-
ATPase (SERCA2a). Phosphorylation of PLB during sympathetic activation reverses …

1 We examined [Ca2+] i and L‐type Ca2+ channel current (ICa) in single cardiac myocytes
to determine how the intracellular protein phospholamban (PLB) influences excitation …

The regulatory protein phospholamban exerts a physiological inhibitory effect on the
sarcoplasmic reticulum (SR) Ca2+ pump that is relieved with phosphorylation. We have …

Phospholamban is a low molecular weight phosphoprotein in cardiac sarcoplasmic
reticulum. The regulatory role of phospholamban in vivo has recently been elucidated by …

Phospholamban (PLB) ablation is associated with enhanced sarcoplasmic reticulum (SR)
Ca2+ uptake and attenuation of the cardiac contractile responses to β-adrenergic agonists …

Phospholamban, the critical regulator of the cardiac SERCA2a Ca2+ affinity, is
phosphorylated at Ser16 and Thr17 during β-adrenergic stimulation (eg, isoproterenol). To …

Entry of Ca2+ through voltage-dependent L-type Ca2+ channels is critical for contraction in
cardiac cells. In recent studies, cells from phospholamban (PLB) knockout (PLB-KO) mouse …