Abstract Background Sclerostin and Dickkopf-related protein-1 (Dkk-1) proteins are
inhibitors of the canonical Wnt/β-catenin bone pathway. Sclerostin but not Dkk-1 is …

Abstract Background: Sclerostin and Dickkopf-1 (Dkk-1) proteins are inhibitors of the
canonical Wnt/β-catenin bone pathway. Pilot data suggest that sclerostin may be involved in …

Abnormalities of bone metabolism and increased vascular calcification are common in
chronic kidney disease (CKD) and important causes of morbidity and mortality. The Wnt …

Introduction Mounting evidence indicates that a disturbed Wnt–β-catenin signaling may be
involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral …

Background The process of vascular calcification has been associated with the canonical
Wnt/β-catenin signalling pathway in cell cultures and animal studies. The relationship …

Purpose To investigate the correlation between elevated serum sclerostin levels and chronic
kidney disease outcomes for patients receiving peritoneal dialysis (PD). Methods We …

Introduction Sclerostin has been reported to be a novel biomarker associated with the bone-
vascular axis. In this study, we determined the relationships between serum sclerostin and …

Abstract Background Sclerostin is a Wnt pathway antagonist regulating osteoblast activity
and bone turnover, and it plays a role in cardiovascular calcification processes. Previous …

Background Derangements in bone metabolism and vascular calcification (VC) substantially
contribute to the accelerated cardiovascular morbidity and mortality in chronic kidney …

For more than a decade, the Wnt–β-catenin pathway has been the focus of intense basic
and clinical research in the bone field because of its importance in skeletal development …