Effects of lung injury on regional aeration and expiratory time constants: insights from four-dimensional computed tomography image registration

J Herrmann, SE Gerard, W Shao, Y Xin… - Frontiers in …, 2021 - frontiersin.org
Rationale: Intratidal changes in regional lung aeration, as assessed with dynamic four-
dimensional computed tomography (CT; 4DCT), may indicate the processes of recruitment …

Temporal dynamics of lung aeration determined by dynamic CT in a porcine model of ARDS

K Markstaller, B Eberle, HU Kauczor… - British journal of …, 2001 - academic.oup.com
We used dynamic CT to identify two different time constants of lung aeration and their
individual contribution to the total increase in cross‐sectional lung area in healthy and …

Spatial heterogeneity of lung strain and aeration and regional inflammation during early lung injury assessed with PET/CT

G Motta-Ribeiro, T Winkler, S Hashimoto, MFV Melo - Academic radiology, 2019 - Elsevier
Introduction Spatial heterogeneity of lung aeration and strain (change volume/resting
volume) occurs at microscopic levels and contributes to lung injury. Yet, it is mostly assessed …

Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury

JB Borges, ELV Costa, F Suarez-Sipmann… - Critical care …, 2014 - journals.lww.com
Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Automatic lung segmentation and quantification of aeration in computed tomography of the chest using 3D transfer learning

L Maiello, L Ball, M Micali, F Iannuzzi, N Scherf… - Frontiers in …, 2022 - frontiersin.org
Background Identification of lung parenchyma on computer tomographic (CT) scans in the
research setting is done semi-automatically and requires cumbersome manual correction …

Regional distribution of lung compliance by image analysis of computed tomograms

G Perchiazzi, C Rylander, S Derosa… - Respiratory physiology …, 2014 - Elsevier
Computed tomography (CT) can yield quantitative information about volume distribution in
the lung. By combining information provided by CT and respiratory mechanics, this study …

Voxel-wise assessment of lung aeration changes on CT images using image registration: application to acute respiratory distress syndrome (ARDS)

M Orkisz, A Morales Pinzón, JC Richard… - International Journal of …, 2019 - Springer
Purpose (1) To improve the accuracy of global and regional alveolar-recruitment
quantification in CT scan pairs by accounting for lung-tissue displacements and …

Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury

JN Cronin, JB Borges, DC Crockett, AD Farmery… - Intensive Care Medicine …, 2019 - Springer
Background Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal,
physiological variation in aeration and lung density in experimental lung injury. The ability of …

Magnetic resonance imaging for quantitative assessment of lung aeration: a pilot translational study

L Ball, A Braune, P Spieth, M Herzog… - Frontiers in …, 2018 - frontiersin.org
Background: Computed tomography is the gold standard for lung aeration assessment, but
exposure to ionizing radiation limits its application. We assessed the ability of magnetic …

Functional respiratory imaging, regional strain, and expiratory time constants at three levels of positive end expiratory pressure in an ex vivo pig model

WR Henderson, Y Molgat‐Seon, W Vos… - Physiological …, 2016 - Wiley Online Library
Heterogeneity in regional end expiratory lung volume (EELV) may lead to variations in
regional strain (ε). High ε levels have been associated with ventilator‐associated lung injury …