Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension
Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide.
The kidney is a major regulator of blood pressure and electrolyte homeostasis, with …
The kidney is a major regulator of blood pressure and electrolyte homeostasis, with …
Uromodulin: from monogenic to multifactorial diseases
F Scolari, C Izzi, GM Ghiggeri - Nephrology Dialysis …, 2015 - academic.oup.com
Uromodulin, the major protein secreted in normal urine, is exclusively produced in the thick
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …
ascending limb (TAL) cells of the kidney. The exact role uromodulin (UMOD) plays in renal …
[HTML][HTML] Unveiling the hidden power of uromodulin: a promising potential biomarker for kidney diseases
R Thielemans, R Speeckaert, C Delrue, S De Bruyne… - Diagnostics, 2023 - mdpi.com
Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary
protein in healthy individuals. Over the years, studies have revealed compelling …
protein in healthy individuals. Over the years, studies have revealed compelling …
Uromodulin: from physiology to rare and complex kidney disorders
O Devuyst, E Olinger, L Rampoldi - Nature Reviews Nephrology, 2017 - nature.com
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …
and is the most abundant protein in normal urine. The function of uromodulin remains …
Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis
M Olden, T Corre, C Hayward, D Toniolo… - Journal of the …, 2014 - journals.lww.com
Uromodulin is expressed exclusively in the thick ascending limb and is the most abundant
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …
protein excreted in normal urine. Variants in UMOD, which encodes uromodulin, are …
Role of uromodulin in salt-sensitive hypertension
S Mary, P Boder, S Padmanabhan, MW McBride… - …, 2022 - Am Heart Assoc
The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …
kidney and cardiovascular research. Genome-wide association studies discovered variants …
Uromodulin: roles in health and disease
C Schaeffer, O Devuyst… - Annual review of …, 2021 - annualreviews.org
Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …
protein in physiological conditions. Already described several decades ago, uromodulin has …
[HTML][HTML] Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension
V Matafora, L Zagato, M Ferrandi, I Molinari, G Zerbini… - BBA clinical, 2014 - Elsevier
Hypertension is a prevalent disorder in the world representing one of the major risk factors
for heart attack and stroke. These risks are increased in salt sensitive individuals …
for heart attack and stroke. These risks are increased in salt sensitive individuals …
Validation of uromodulin as a candidate gene for human essential hypertension
LA Graham, S Padmanabhan, NJ Fraser, S Kumar… - …, 2014 - Am Heart Assoc
A recent genome-wide association study identified a locus on chromosome 16 in the
promoter region of the uromodulin (UMOD) gene that is associated with hypertension. Here …
promoter region of the uromodulin (UMOD) gene that is associated with hypertension. Here …
Uromodulin biology and pathophysiology–an update
P Vyletal, AJ Bleyer, S Kmoch - Kidney and Blood Pressure Research, 2010 - karger.com
Uromodulin (UMOD) is a glycoprotein expressed on the luminal surface of the apical
membrane of renal tubular epithelial cells forming the thick ascending limb of Henle. Here …
membrane of renal tubular epithelial cells forming the thick ascending limb of Henle. Here …