[HTML][HTML] An IFNT/FOXO1/PTGS2 axis regulates prostaglandin F2α synthesis in goat uterus during early pregnancy

LG Bu, B Wang, TY Li, Y Sun, LL Kong, ZA Zhao… - Journal of Dairy …, 2023 - Elsevier
In ruminants, IFN-tau (IFNT) regulates the production of prostaglandins (PG) in the
endometrium, which is crucial for conceptus adhesion. However, the related molecular …

Epidermal growth factor: Expression in goat endometrial epithelia during early pregnancy and regulation by interferon tau and FOXO1

B Wang, MD Li, HY Xu, XC Zhang, LG Bu, TY Li… - Animal Reproduction …, 2024 - Elsevier
In ruminants, establishment and maintenance of pregnancy depends upon a well-
coordinated interaction between the conceptus and the maternal endometrium. Epidermal …

Endometrial factors similarly induced by IFNT2 and IFNTc1 through transcription factor FOXS1

K Kusama, R Bai, K Nakamura, S Okada, J Yasuda… - PloS one, 2017 - journals.plos.org
In ruminants, Interferon tau (IFNT) is the pregnancy recognition protein produced by the
mononuclear trophectoderm of the conceptus, and is secreted into the uterine lumen during …

FOXL2 is a Progesterone Target Gene in the Endometrium of Ruminants

C Eozenou, A Lesage-Padilla, V Mauffré… - International journal of …, 2020 - mdpi.com
Forkhead Box L2 (FOXL2) is a member of the FOXL class of transcription factors, which are
essential for ovarian differentiation and function. In the endometrium, FOXL2 is also thought …

FOXL2 is regulated during the bovine estrous cycle and its expression in the endometrium is independent of conceptus-derived interferon tau

C Eozenou, AV Carvalho, N Forde… - Biology of …, 2012 - academic.oup.com
Abstract FOXL2, a winged-helix/forkhead domain transcription factor, is a key gene involved
in the differentiation and biological functions of the ovary. In a recent transcriptomic analysis …

FOXO3 expression and function in the pig oocyte and embryo

C Yang, EC Wright, BJ Hale… - Iowa State University …, 2013 - iastatedigitalpress.com
Abstract Forkhead box O3 (FOXO3), a member of the FOXO subfamily of Forkhead
transcription factors, has been shown to play critical roles in apoptosis, oxidative stress, cell …

Transcriptomic analysis of STAT1/3 in the goat endometrium during embryo implantation

H Liu, C Wang, Z Li, C Shang, X Zhang… - Frontiers in Veterinary …, 2021 - frontiersin.org
Interferon tau (IFNT), a pregnancy recognition signal in ruminants, promotes the
establishment of embryo implantation by inducing the expression of interferon-stimulated …

PPARγ/mTOR regulates the synthesis and release of prostaglandins in ovine trophoblast cells in early pregnancy

K Hao, J Wang, Z Li, H Chen, B Jia, G Hu - Veterinary Sciences, 2022 - mdpi.com
Simple Summary During early gestation, a series of prostaglandins are synthesized and
secreted by the sheep's conceptus. The ratio of PGE2 to PGF2α is very important for embryo …

Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus

MB Rashid, AK Talukder, K Kusama, S Haneda… - Biochemical and …, 2018 - Elsevier
Recent studies suggest that Day-7 bovine embryo starts to communicate with the uterine
epithelium through interferon-tau (IFNT) signaling. However, immune modulatory role of …

Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNτ directs normal uterine fate for bovine early implantation

X Wang, C Chen, L Wang, Y Su, B Li, L Xiao… - Journal of Reproductive …, 2022 - Elsevier
Abstract Interferon-tau (IFNτ), as an antiluteolytic factor secreted by trophoderm during the
pregnancy of ruminants, actually functions by activating the IFNτ receptor 1 (IFNAR1) and …