The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity

A Gonzalez-Martin, BD Adams, M Lai, J Shepherd… - Nature …, 2016 - nature.com
Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the
molecular pathways that control these cells remain poorly understood. We performed an in …

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production

Y Mok, V Schwierzeck, DC Thomas… - The Journal of …, 2013 - journals.aai.org
MicroRNAs (MiRs) are small, noncoding RNAs that regulate gene expression
posttranscriptionally. In this study, we show that MiR-210 is induced by Oct-2, a key …

[HTML][HTML] Regulation of B-cell development and tolerance by different members of the miR-17∼ 92 family microRNAs

M Lai, A Gonzalez-Martin, AB Cooper, H Oda… - Nature …, 2016 - nature.com
The molecular mechanisms that regulate B-cell development and tolerance remain
incompletely understood. In this study, we identify a critical role for the miR-17∼ 92 …

Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Faslpr mouse

TH Thai, HC Patterson, DH Pham… - Proceedings of the …, 2013 - National Acad Sciences
MicroRNA-155 (miR-155) regulates antibody responses and subsequent B-cell effector
functions to exogenous antigens. However, the role of miR-155 in systemic autoimmunity is …

The microRNA-212/132 cluster regulates B cell development by targeting Sox4

A Mehta, M Mann, JL Zhao, GK Marinov… - Journal of Experimental …, 2015 - rupress.org
MicroRNAs have emerged as key regulators of B cell fate decisions and immune function.
Deregulation of several microRNAs in B cells leads to the development of autoimmune …

Silencing of microRNA‐21 in vivo ameliorates autoimmune splenomegaly in lupus mice

BG Garchow, O Bartulos Encinas, YT Leung… - EMBO molecular …, 2011 - embopress.org
MicroRNAs (miRNAs) have been implicated in B cell lineage commitment, regulation of T
cell differentiation, TCR signalling, regulation of IFN signalling, and numerous other …

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

S Zhu, W Pan, X Song, Y Liu, X Shao, Y Tang… - Nature medicine, 2012 - nature.com
Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune
diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune …

[HTML][HTML] MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development

RM O'Connell, D Kahn, WSJ Gibson, JL Round… - Immunity, 2010 - cell.com
Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been
linked to immune system function. Here, we have investigated the role of miR-155 during an …

miR-155 indicates the fate of CD4+ T cells

L Chen, D Gao, Z Shao, Q Zheng, Q Yu - Immunology Letters, 2020 - Elsevier
MicroRNAs (miRNAs) are a class of short noncoding RNAs that regulate the translation of
target messenger RNA (mRNA) and consequently participate in a variety of biological …

[HTML][HTML] MicroRNA-155 influences B-cell function through PU. 1 in rheumatoid arthritis

S Alivernini, M Kurowska-Stolarska, B Tolusso… - Nature …, 2016 - nature.com
Abstract MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a
critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is …