[HTML][HTML] Modes of action of intravenous immunoglobulin in bullous pemphigoid

N Li, D Culton, LA Diaz, Z Liu - Journal of Investigative Dermatology, 2018 - Elsevier
Bullous pemphigoid is an autoantibody-mediated skin blistering disease. Previous studies
revealed that intravenous Ig is therapeutic in animal models of bullous pemphigoid by …

[HTML][HTML] Intravenous IgG reduces pathogenic autoantibodies, serum IL-6 levels, and disease severity in experimental bullous pemphigoid models

T Sasaoka, H Ujiie, W Nishie, H Iwata… - Journal of investigative …, 2018 - Elsevier
Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by
autoantibodies to COL17. Currently, systemic corticosteroids are used as first-line treatments …

[HTML][HTML] Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases

N Li, M Zhao, J Hilario-Vargas… - The Journal of …, 2005 - Am Soc Clin Investig
Numerous mechanisms of action have been proposed for intravenous Ig (IVIG). In this study,
we used IgG passive transfer murine models of bullous pemphigoid (BP), pemphigus …

[HTML][HTML] Increasing the complement of therapeutic options in bullous pemphigoid

CJ Kushner, AS Payne - Journal of Investigative Dermatology, 2018 - Elsevier
Bullous pemphigoid is a potentially life-threatening autoantibody-mediated dermatosis
characterized by blister formation. Experimental mouse models of bullous pemphigoid …

[HTML][HTML] Bullous pemphigoid: a prototypical antibody-mediated organ-specific autoimmune disease

C Sitaru - Journal of Investigative Dermatology, 2009 - Elsevier
Bullous pemphigoid (BP) is a prototypical organ-specific autoimmune disease.
Autoantibodies unfold their blister-inducing potential by triggering an Fcγ-dependent …

Role of intravenous immunoglobulin in the treatment of bullous pemphigoid: analysis of current data

L Engineer, AR Ahmed - Journal of the American Academy of Dermatology, 2001 - Elsevier
Background: Conventional therapy of severe bullous pemphigoid (BP) relies on the use of
high-dose systemic corticosteroids with or without adjuvants, notably immunosuppressive …

Immunopathology of bullous pemphigoid, an autoimmune and inflammatory skin blistering disease

Z Liu - The Keio journal of medicine, 2003 - jstage.jst.go.jp
Bullous pemphigoid (BP) was first described by Lever in 1953 as a subepidermal blistering
disease. Key immunohistological features of BP include dermo-epidermal junction (DEJ) …

Improvement of intravenous immunoglobulin therapy for bullous pemphigoid by adding immunosuppressive agents: marked improvement in depletion of circulating …

A Czernik, JC Bystryn - Archives of dermatology, 2008 - jamanetwork.com
Background Various antibody-mediated autoimmune disorders are treated with intravenous
immunoglobulin (IVIg). While the exact action of IVIg is unknown, it likely acts to rapidly and …

[HTML][HTML] A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice

JA Fairley, CT Burnett, CL Fu, DL Larson… - Journal of investigative …, 2007 - Elsevier
Bullous pemphigoid (BP) is an autoimmune disease characterized by subepidermal
blistering. Based on previous work, IgG autoantibodies directed against BP180 are thought …

FcR-independent effects of IgE and IgG autoantibodies in bullous pemphigoid

KN Messingham, R Srikantha… - The Journal of …, 2011 - journals.aai.org
Bullous pemphigoid (BP) is a subepidermal blistering disease characterized by IgE and IgG
class autoantibodies specific for 180-kDa BP Ag 2 (BP180), a protein involved in cell …