Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review

YP Singh, H Kumar - Chemical Biology & Drug Design, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a chronic age‐related neurodegenerative brain disorder
characterized by the impairment of memory accompanied by worsening of thinking ability of …

Synthesis, in silico, and evaluation of AChE inhibitory activity of N-phthaloylphenylglycine derivatives as potential anti-Alzheimer's agents

E Andrade-Jorge, N Reyes-Vallejo… - Medicinal Chemistry …, 2023 - Springer
Mental illnesses are one of the most relevant health problems today, among which
Alzheimer's disease (AD) stands out. This is a severe disease that entails different …

[HTML][HTML] Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease

K Gajendra, GK Pratap, DV Poornima… - European Journal of …, 2024 - Elsevier
Abstract Alzheimer's disease (AD), the main dementia type accounting for over 70% of the
entire dementia population, progressive decline in memory and executive function. AD …

Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile

K Sobolova, M Hrabinova, V Hepnarova… - European journal of …, 2020 - Elsevier
Berberine, a naturally occurring compound, possesses an interesting multipotent
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …

Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors

G Turan-Zitouni, W Hussein, BN Saglik… - Letters in Drug …, 2018 - ingentaconnect.com
Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a
multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language …

Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies

V Machado, AR Cenci, KF Teixeira, L Sens… - RSC Medicinal …, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized as the main
dementia in the elderly. Eighteen pyrazolines were synthesized and evaluated for their …

Acetylcholinesterase inhibitory potential of various sesquiterpene analogues for Alzheimer's disease therapy

A Arya, R Chahal, R Rao, MH Rahman, D Kaushik… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is a gradually growing irreversible illness of the brain that almost
affects every fifth person (aged> 80 years) in the world. World Health Organization (WHO) …

Synthesis and In Vitro Assessment of Anticholinesterase and Antioxidant Properties of Triazineamide Derivatives

M Vatturu, KY Rao, VB Yesu, SJ Basha… - Future Medicinal …, 2022 - Taylor & Francis
Aim: Cholinesterase inhibitors and radical scavengers have been recognized as powerful
symptomatic anti-Alzheimer's disease agents. Hence, the present study aimed to develop …

Benzofurans as Acetylcholinesterase Inhibitors for Treating Alzheimer's Disease: Synthesis, in vitro Testing, and in silico Analysis

A Coaviche‐Yoval, R Tovar‐Miranda… - …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of
dementia worldwide. It is characterized by a progressive decline in cholinergic …

Synthesis and biological evaluation of new cholinesterase inhibitors for Alzheimer's disease

W Hussein, BN Sağlık, S Levent, B Korkut, S Ilgın… - Molecules, 2018 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly,
and causes death due to dementia. The main pathogenic feature connected with the …