Is it time to move to multidrug combinations?

JL Pool - American journal of hypertension, 2003 - academic.oup.com
The clinical benefit of aggressive blood pressure (BP) control in reducing adverse
cardiovascular and renal outcomes is well documented. However, a majority of patients with …

The need for combination antihypertensive therapy to reach target blood pressures: what has been learned from clinical practice and morbidity–mortality trials?

HAJ Struijker‐Boudier, E Ambrosioni… - … journal of clinical …, 2007 - Wiley Online Library
Pharmacological treatment of hypertension represents a cost‐effective way for preventing
cardiovascular and renal complications. To benefit maximally from antihypertensive …

Antihypertensive combination therapy: optimizing blood pressure control and cardiovascular risk reduction

SD Nesbitt - The Journal of Clinical Hypertension, 2007 - Wiley Online Library
Treating hypertension reduces the rates of myocardial infarction, stroke, and renal disease;
however, clinical trial experience suggests that monotherapy is not likely to be successful for …

[HTML][HTML] Rational approaches to the treatment of hypertension: drug therapy—monotherapy, combination, or fixed-dose combination?

B Canbakan - Kidney international supplements, 2013 - Elsevier
Blood pressure (BP) control is inadequate worldwide. Many clinical trials suggest that BP is
not satisfactorily controlled using monotherapy in most patients. Free drug or fixed-dose …

Managing hypertension in high-risk patients: lessons and promises from the STRATHE and ADVANCE trials

B Waeber - Journal of Hypertension, 2006 - journals.lww.com
Pharmacological treatment of hypertension represents a cost-effective way of preventing
cardiovascular and renal complications. To benefit maximally from antihypertensive …

Fixed and low-dose combinations of blood pressure-lowering agents: for the many or the few?

M Leggio, A Fusco, C Loreti, G Limongelli, MG Bendini… - Drugs, 2019 - Springer
Despite the widespread availability of several effective classes of drugs, systemic arterial
hypertension remains poorly controlled in the majority of patients worldwide. In this article …

Combination drug treatment of hypertension: have we come full circle?

AA Taylor - Current Cardiology Reports, 2004 - Springer
Only 30% of hypertensive patients achieved and maintained adequate blood pressure
control on a single drug in recent clinical trials. For the majority of patients who require two …

Improving blood pressure control rates by optimizing combination antihypertensive therapy

BJ Epstein - Expert opinion on pharmacotherapy, 2010 - Taylor & Francis
Importance of the field: Hypertension is the most common preventable cause of
cardiovascular morbidity and mortality. Despite the availability of a multitude of …

Combination therapy in hypertension

AH Gradman, JN Basile, BL Carter… - The Journal of …, 2011 - Wiley Online Library
Editor's Note: The American Society of Hypertension is publishing a series of Position
Papers in their official journals throughout the 2008–2011 years. The following Position …

Dispelling the myth of “aggressive” antihypertensive therapy

EO Ofili - The Journal of Clinical Hypertension, 2006 - Wiley Online Library
Data from well designed randomized trials have proven the effectiveness of an intensive
approach to hypertension management in reducing morbidity and mortality. Based on these …