Effects of acute, profound hypoxia on healthy humans: implications for safety of tests evaluating pulse oximetry or tissue oximetry performance

PE Bickler, JR Feiner, MS Lipnick… - Anesthesia & …, 2017 - journals.lww.com
SoCIETy researchers became focused on altitude effects on humans and other animals.
West5 has written a comprehensive recent review on the history of these early altitude …

Facing acute hypoxia: from the mountains to critical care medicine

MM Berger, MPW Grocott - BJA: British Journal of Anaesthesia, 2017 - academic.oup.com
It was not until 1978 that, after many unsuccessful attempts, the summit of Mount Everest
(8850 m) was reached by climbers breathing only ambient air. This challenge was first …

High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine

M Grocott, H Montgomery, A Vercueil - Critical Care, 2007 - Springer
Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human
responses to hypoxia occurring as a consequence of hypobaria defines the fields of high …

Hypoxia: developments in basic science, physiology and clinical studies

DS Ward, SB Karan, JJ Pandit - Anaesthesia, 2011 - Wiley Online Library
Airway management is primarily designed to avoid hypoxia, yet hypoxia remains the main
ultimate cause of anaesthetic‐related death and morbidity. Understanding some of the …

Oxygen sensing, homeostasis, and disease

GL Semenza - New England Journal of Medicine, 2011 - Mass Medical Soc
Pathways that sense a reduction in available oxygen are critical in the adaptation to lower
oxygen tensions at high altitude. Alterations in this system can contribute to the …

From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia

D Martin, J Windsor - Postgraduate medical journal, 2008 - academic.oup.com
For centuries man has strived to reach the greatest heights on earth. In order to explain the
physiological changes that are needed to achieve this, physiologists have tended to focus …

The physiology of high altitude: an introduction to the cardio-respiratory changes occurring on ascent to altitude

NP Mason - Current Anaesthesia & Critical Care, 2000 - Elsevier
Both the high altitude physiologist and the intensivist are challenged by the human organism
in a hypoxic environment. The variation in barometric pressure which occurs with latitude …

Humans at altitude: physiology and pathophysiology

JPR Brown, MPW Grocott - … in Anaesthesia, Critical Care & Pain, 2013 - academic.oup.com
Barometric pressure (PB) decreases in a nonlinear fashion with altitude, vertical height gain
above the Earth's surface. The percentage of oxygen in the atmosphere remains constant …

Microcirculatory and mitochondrial hypoxia in sepsis, shock, and resuscitation

C Ince, EG Mik - Journal of applied physiology, 2016 - journals.physiology.org
After shock, persistent oxygen extraction deficit despite the apparent adequate recovery of
systemic hemodynamic and oxygen-derived variables has been a source of uncertainty and …

Tolerance to severe hypoxia: lessons from Mt. Everest

JB West - Acta Anaesthesiologica Scandinavica, 1990 - Wiley Online Library
Human tolerance to chronic severe hypoxia has been elucidated by two recent high altitude
studies: the 1981 American Medical Research Expedition to Everest, and Operation Everest …