Fixed-dose combination antihypertensives and reduction in target organ damage: are they all the same?
DHG Smith - American journal of cardiovascular drugs, 2007 - Springer
Hypertension is a multifactorial disorder leading to pathophysiologic changes in target
organs over time through diverse mechanisms. In addition, hypertension frequently resists …
organs over time through diverse mechanisms. In addition, hypertension frequently resists …
Low dose combination antihypertensive therapy: additional efficacy without additional adverse effects?
AM MacConnachie, D Maclean - Drug safety, 1995 - Springer
Conclusion The careful selection of first-line antihypertensive therapy using a variety of drug
combinations might enable more precise control of hypertension at low dosage and in the …
combinations might enable more precise control of hypertension at low dosage and in the …
Improving blood pressure control rates by optimizing combination antihypertensive therapy
BJ Epstein - Expert opinion on pharmacotherapy, 2010 - Taylor & Francis
Importance of the field: Hypertension is the most common preventable cause of
cardiovascular morbidity and mortality. Despite the availability of a multitude of …
cardiovascular morbidity and mortality. Despite the availability of a multitude of …
Low-dose antihypertensive combination therapy: its rationale and role in cardiovascular risk management
JM Neutel - American journal of hypertension, 1999 - academic.oup.com
Antihypertensive monotherapy, although commonly used, does not address the
multifactorial nature of hypertension as a disease with many pathways. Using more than one …
multifactorial nature of hypertension as a disease with many pathways. Using more than one …
Emerging Insights in the First‐Step Use of Antihypertensive Combination Therapy
K Norris, JM Neutel - The Journal of Clinical Hypertension, 2007 - Wiley Online Library
The blood pressure (BP) goals set by hypertension management guidelines (< 140/90 mm
Hg in uncomplicated hypertension;< 130/80 mm Hg in type 2 diabetes or kidney disease) …
Hg in uncomplicated hypertension;< 130/80 mm Hg in type 2 diabetes or kidney disease) …
The need for combination antihypertensive therapy to reach target blood pressures: what has been learned from clinical practice and morbidity–mortality trials?
HAJ Struijker‐Boudier, E Ambrosioni… - … journal of clinical …, 2007 - Wiley Online Library
Pharmacological treatment of hypertension represents a cost‐effective way for preventing
cardiovascular and renal complications. To benefit maximally from antihypertensive …
cardiovascular and renal complications. To benefit maximally from antihypertensive …
Fixed and low-dose combinations of blood pressure-lowering agents: for the many or the few?
M Leggio, A Fusco, C Loreti, G Limongelli, MG Bendini… - Drugs, 2019 - Springer
Despite the widespread availability of several effective classes of drugs, systemic arterial
hypertension remains poorly controlled in the majority of patients worldwide. In this article …
hypertension remains poorly controlled in the majority of patients worldwide. In this article …
Creating a combination antihypertensive regimen: what does the research show?
MA Weber - The Journal of Clinical Hypertension, 2003 - Wiley Online Library
Major randomized clinical trials have demonstrated unquestionable clinical benefits of
lowering blood pressure without establishing superiority of any specific antihypertensive …
lowering blood pressure without establishing superiority of any specific antihypertensive …
[HTML][HTML] Combination therapy in the treatment of hypertension
C Guerrero-García, AF Rubio-Guerra - Drugs in context, 2018 - ncbi.nlm.nih.gov
Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart
disease. Although modern and effective antihypertensive drugs are available, most patients …
disease. Although modern and effective antihypertensive drugs are available, most patients …
Present and future role of combination treatment in hypertension
G Mancia, M Failla, A Grappiolo… - Journal of …, 1998 - journals.lww.com
Both in clinical practice and in drug trials, combination treatment of hypertension plays a
fundamental role. This article reviews the features that make combined therapy with two …
fundamental role. This article reviews the features that make combined therapy with two …