Hypertension is a multifactorial disorder leading to pathophysiologic changes in target
organs over time through diverse mechanisms. In addition, hypertension frequently resists …

Conclusion The careful selection of first-line antihypertensive therapy using a variety of drug
combinations might enable more precise control of hypertension at low dosage and in the …

Importance of the field: Hypertension is the most common preventable cause of
cardiovascular morbidity and mortality. Despite the availability of a multitude of …

Antihypertensive monotherapy, although commonly used, does not address the
multifactorial nature of hypertension as a disease with many pathways. Using more than one …

The blood pressure (BP) goals set by hypertension management guidelines (< 140/90 mm
Hg in uncomplicated hypertension;< 130/80 mm Hg in type 2 diabetes or kidney disease) …

Pharmacological treatment of hypertension represents a cost‐effective way for preventing
cardiovascular and renal complications. To benefit maximally from antihypertensive …

Despite the widespread availability of several effective classes of drugs, systemic arterial
hypertension remains poorly controlled in the majority of patients worldwide. In this article …

Major randomized clinical trials have demonstrated unquestionable clinical benefits of
lowering blood pressure without establishing superiority of any specific antihypertensive …

Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart
disease. Although modern and effective antihypertensive drugs are available, most patients …

Both in clinical practice and in drug trials, combination treatment of hypertension plays a
fundamental role. This article reviews the features that make combined therapy with two …