The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …

The normal aging process is a complex phenomenon associated with physiological
alterations in the function of cells and organs over time. Although an attractive candidate for …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …

The genomic hypomethylation hypothesis of aging proposes that an overall decrease in
global DNA methylation occurs with age, and it has been argued that the decrease in global …

Cancer and aging are two coupled developmental processes as reflected by the higher
incidence of cancer in the elderly human population group. Genetic mutations accumulate in …

DNA methylation plays an essential role in maintaining cellular function, and changes in
methylation patterns may contribute to the development of autoimmunity, aging and cancer …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …