Impact of aging on DNA methylation
B Richardson - Ageing research reviews, 2003 - Elsevier
The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …
[HTML][HTML] The role of DNA methylation in epigenetics of aging
A Unnikrishnan, WM Freeman, J Jackson… - Pharmacology & …, 2019 - Elsevier
Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …
Epigenetic clock: DNA methylation in aging
S Jiang, Y Guo - Stem cells international, 2020 - Wiley Online Library
Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …
incidence, limits human lifespan and has attracted investigators for thousands of years. In …
Tissue‐specific dysregulation of DNA methylation in aging
The normal aging process is a complex phenomenon associated with physiological
alterations in the function of cells and organs over time. Although an attractive candidate for …
alterations in the function of cells and organs over time. Although an attractive candidate for …
DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Continuous aging of the human DNA methylome throughout the human lifespan
Å Johansson, S Enroth, U Gyllensten - PloS one, 2013 - journals.plos.org
DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
Revisiting the genomic hypomethylation hypothesis of aging
The genomic hypomethylation hypothesis of aging proposes that an overall decrease in
global DNA methylation occurs with age, and it has been argued that the decrease in global …
global DNA methylation occurs with age, and it has been argued that the decrease in global …
Aging, cancer and nutrition: the DNA methylation connection
L Liu, RC Wylie, LG Andrews, TO Tollefsbol - Mechanisms of ageing and …, 2003 - Elsevier
Cancer and aging are two coupled developmental processes as reflected by the higher
incidence of cancer in the elderly human population group. Genetic mutations accumulate in …
incidence of cancer in the elderly human population group. Genetic mutations accumulate in …
[HTML][HTML] Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer
BC Richardson - The Journal of nutrition, 2002 - Elsevier
DNA methylation plays an essential role in maintaining cellular function, and changes in
methylation patterns may contribute to the development of autoimmunity, aging and cancer …
methylation patterns may contribute to the development of autoimmunity, aging and cancer …
[HTML][HTML] DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
F Ciccarone, S Tagliatesta, P Caiafa… - Mechanisms of ageing …, 2018 - Elsevier
DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …
predicting life expectancy. However, the mechanisms underlying age-related DNA …