Abstract The pleiotropic Ca 2+/calmodulin-dependent phosphatase calcineurin is a key
regulator of pathological cardiac myocyte hypertrophy. The selective activation of …

Maladaptive cardiac hypertrophy can progress to congestive heart failure, a leading cause
of morbidity and mortality in the United States. A better understanding of the intracellular …

mAKAPβ is the scaffold for a multimolecular signaling complex in cardiac myocytes that is
required for the induction of neonatal myocyte hypertrophy. We now show that the pro …

Cardiac hypertrophy is regulated by a large intracellular signal transduction network. Each
of the many signaling pathways in this network contributes uniquely to the control of cell …

The physical association of regulatory enzymes and ion channels at relevant intracellular
sites contributes to the diversity and specificity of second messenger-mediated signal …

Background: The Ca2+/calmodulin-dependent phosphatase calcineurin is a key regulator of
cardiac myocyte hypertrophy in disease. An unexplained paradox is how the β isoform of the …

Cardiac remodeling is regulated by an extensive intracellular signal transduction network.
Each of the many signaling pathways in this network contributes uniquely to the control of …

Rationale: Pathological cardiac myocyte hypertrophy is thought to be induced by the
persistent increases in intracellular Ca2+ needed to maintain cardiac function when systolic …

Abstract The ubiquitous Ca2+/calmodulin‐dependent phosphatase calcineurin is a key
regulator of pathological cardiac hypertrophy whose therapeutic targeting in heart disease …

Cardiac hypertrophy is a leading predicator of progressive heart disease that often leads to
heart failure and a loss of cardiac contractile performance associated with profound …