Objectives: Determine the intra-tidal regional gas and blood volume distributions at different
levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration …

Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Objective: Cyclic recruitment and derecruitment of atelectasis can occur during mechanical
ventilation, especially in injured lungs. Experimentally, cyclic recruitment and derecruitment …

Objectives: We recently described how spontaneous effort during mechanical ventilation can
cause “pendelluft,” that is, displacement of gas from nondependent (more recruited) lung to …

Both overdistension and atelectasis contribute to lung injury and mortality during mechanical
ventilation. It has been proposed that combinations of tidal volume and end-expiratory lung …

Objective: In acute lung injury (ALI) mechanical ventilation damages lungs. We
hypothesised that aspiration and replacement of dead space during expiration (ASPIDS) …

Objective: We investigated whether potentially injurious transpulmonary pressure could be
generated by strong spontaneous breathing and exacerbate lung injury even when plateau …

Objective We utilized in vivo microscopy to measure the impact of increasing tidal volume on
individual alveolar mechanics (ie, the dynamic change in alveolar size during tidal …

Lung perfusion magnitude and distribution are essential for oxygenation and, potentially,
lung inflammation and protection during acute respiratory distress syndrome (ARDS). Yet …

Alveolar recruitment in combination with sufficient positive... : Critical Care Medicine Alveolar
recruitment in combination with sufficient positive end-expiratory pressure increases oxygenation …