Simple Summary Different connexins play diverse roles in cancers, either tumor-
suppressing or tumor-promoting. In lung cancer, Cx43 serves as a tumor suppressor at the …

Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …

Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct
information exchange between cells. Cx expression has a strong spatial specificity; …

Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Gap junctions are membrane channels found in all cells of the human body that are
essential to cellular physiology. Gap junctions are formed from connexin proteins and are …

Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …