Since their discovery, the study of maternal mRNA s has led to the identification of
mechanisms underlying their spatiotemporal regulation within the context of oogenesis and …

Introduction 3. Post-Transcriptional Control Mechanisms for Maternal mRNA Repression 3.1.
Deadenylation of Maternal mRNA 3.2. Masking of Maternal mRNA: Nonspecific Interaction …

Transcription ceases upon stimulation of oocyte maturation and gene expression during
oocyte maturation, fertilization, and early cleavage relies on translational activation of …

Oocytes accumulate a dowry of maternal mRNAs in preparation for embryogenesis. These
maternal transcripts are kept dormant until late oogenesis or early embryogenesis when …

Over 75 years ago, embryologists had already established that cytoplasmic components
could program early development even in the absence of nuclear material. Although …

The poly (A)‐dependent translational regulation of maternal mRNAs is an important
mechanism to execute stage‐specific programs of protein synthesis during early …

Transcriptional activation in mammalian embryos occurs in a stepwise manner. In mice, it
begins at the late one-cell stage, followed by a minor wave of activation at the early two-cell …

In somatic cells, RNA polymerase II (Pol II) transcription initiation starts by the binding of the
general transcription factor TFIID, containing the TATA-binding protein (TBP) and 13 TBP …

mRNA regulation is essential in germ cells and early embryos. In particular, late oogenesis
and early embryogenesis occur in the absence of transcription and rely on maternal mRNAs …

The maternal mRNAs that drive meiotic progression in oocytes contain short poly (A) tails
and it is only when these tails are elongated that translation takes place. Cytoplasmic …