A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria

MK Laufer, PC Thesing, FK Dzinjalamala, OM Nyirenda… - 2012 - journals.plos.org
Background The predominance of chloroquine-susceptible falciparum malaria in Malawi
more than a decade after chloroquine's withdrawal permits contemplation of re-introducing …

Return of chloroquine antimalarial efficacy in Malawi

MK Laufer, PC Thesing, ND Eddington… - … England Journal of …, 2006 - Mass Medical Soc
Background In 1993, Malawi became the first country in Africa to replace chloroquine with
the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time …

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum

S Dunyo, R Ord, R Hallett, M Jawara… - PLoS clinical …, 2006 - journals.plos.org
Objectives In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-
pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by …

Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa

PB Bloland, EM Lackritz, PN Kazembe… - Journal of infectious …, 1993 - academic.oup.com
Emphasis on retaining chloroquine as the first-line therapy for Plasmodium falciparum
infections in most of sub-Saharan Africa for as long as it remains effective has resulted in …

Predictors of the failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high and increasing …

A Sowunmi, BA Fateye, AA Adedeji… - Annals of Tropical …, 2005 - Taylor & Francis
Resistance to chloroquine (CQ) in Plasmodium falciparum has reached unacceptably high
levels in many endemic countries. The pre-treatment factors that identify the children who …

Chloroquine is grossly under dosed in young children with malaria: implications for drug resistance

J Ursing, S Eksborg, L Rombo, Y Bergqvist… - PLoS …, 2014 - journals.plos.org
Background Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ)
irrespective of age. Theoretically, CQ should be dosed according to body surface area …

[HTML][HTML] Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine+ sulfadoxine-pyrimethamine and chloroquine+ …

TO Ogungbamigbe, O Ojurongbe… - Memórias do Instituto …, 2008 - SciELO Brasil
Chloroquine (CQ) resistance in Plasmodium falciparum contributes to increasing malaria-
attributable morbidity and mortality in Sub-Saharan Africa. Despite a change in drug policy …

[PDF][PDF] Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.

G Dorsey, MR Kamya, G Ndeezi, JN Babirye… - The American journal …, 2000 - academia.edu
Chloroquine-resistant falciparum malaria is a serious problem in much of sub-Saharan
Africa. However, it is desirable to continue to use chloroquine as first-line therapy for …

Efficacy of chloroquine and sulfadoxine/pyrimethamine for the treatment of uncomplicated falciparum malaria in Koumantou, Mali

X de Radigues, KI Diallo, M Diallo… - Transactions of the …, 2006 - academic.oup.com
We report the results of an in vivo antimalarial efficacy study with chloroquine (CQ) and
sulfadoxine/pyrimethamine (SP) conducted between 2003 and 2004 in Koumantou …

Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana

S Ehrhardt, FP Mockenhaupt… - Annals of Tropical …, 2002 - Taylor & Francis
Chloroquine (CQ) resistance in Plasmodium falciparum contributes to growing malaria-
attributable morbidity and mortality in sub-Saharan Africa. However, the extent and degree …